INT142802

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.08
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
adipocyte 3
plasma 1
hepatocytes 1
endothelial cells 1
heart 1
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 36 99.40 Very High Very High Very High
noradrenaline 42 97.64 Very High Very High Very High
long-term potentiation 12 89.48 High High
Angina 4 77.32 Quite High
ischemia 1 66.08 Quite High
nMDA receptor 5 50.88 Quite High
cytokine 16 44.44 Quite Low
Inflammation 30 44.04 Quite Low
antagonist 3 37.28 Quite Low
tolerance 3 28.48 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 89 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

26 100.00 Very High Very High Very High
Hypertriglyceridemia 12 100.00 Very High Very High Very High
Coronary Heart Disease 6 100.00 Very High Very High Very High
Obesity 254 99.84 Very High Very High Very High
Atherosclerotic Plaque 28 98.16 Very High Very High Very High
Targeted Disruption 44 92.56 High High
Disease 69 91.44 High High
Hyperlipoproteinemia Type Ii 132 89.96 High High
Hyperlipidemia 44 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are numerous possibilities for how the interaction between apoB100-LDL and adipocyte LDLR may influence catecholamine signaling to the adipose tissue.
apoB100-LDL Binding (interaction) of in adipocyte associated with catecholamine and obesity
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.68 Pain Relevance 0.16
There are numerous possibilities for how the interaction between apoB100-LDL and adipocyte LDLR may influence catecholamine signaling to the adipose tissue.
adipocyte LDLR Binding (interaction) of in adipocyte associated with catecholamine and obesity
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.68 Pain Relevance 0.16
When applied in vivo following hydrodynamic injection [91], this protein was shown to bind circulating plasma LDL and to mediate its clearance through the transferrin receptor on hepatocytes.
plasma LDL Binding (bind) of in hepatocytes
3) Confidence 0.38 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.17 Pain Relevance 0
Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes.
apoB100-LDL Binding (he bind) of in adipocytes associated with obesity and noradrenaline
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2582480 Disease Relevance 0.65 Pain Relevance 0.08
The strategy of this approach was based on the ability of the fusion protein to be capable of binding both plasma LDL and the cellular transferrin receptor.
plasma LDL Binding (binding) of in plasma
5) Confidence 0.33 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.18 Pain Relevance 0
Of the two major apolipoproteins found in the CSF, apoE can associate to a number of extracellular molecules and bind to four major CNS apoE receptors; VLDLR, ApoER2, LDLR and LRP.
LDLR Binding (bind) of
6) Confidence 0.15 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.66 Pain Relevance 0.14
After 7 days of culture, endothelial cells differentiated from EPCs were identified as adherent cells with 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine-labeled acetylated low density lipoprotein (Dil-Ac-LDL) uptake and lectin binding under a fluorescent microscope.
Dil-Ac-LDL Binding (binding) of in endothelial cells
7) Confidence 0.03 Published 2006 Journal Hypertens. Res. Section Abstract Doc Link 17378377 Disease Relevance 0.15 Pain Relevance 0.08
This trial, jointly sponsored by the US National Heart, Lung, and Blood Institute and Kos Pharmaceuticals Inc (now Abbott Pharmaceuticals), is currently recruiting a population of 3300 patients with established coronary heart disease, atherogenic dyslipidemia (low HDL-cholesterol and high TG), and LDL-cholesterol controlled to current US guideline goals (NCEP criteria) at 60 sites in the US and Canada.
LDL-cholesterol Binding (population) of in heart associated with hypertriglyceridemia, coronary heart disease and disorder of lipid metabolism
8) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 1.12 Pain Relevance 0.03
have a high affinity for GAGs and for the LDL receptor.
LDL receptor Binding (affinity) of
9) Confidence 0.02 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.50 Pain Relevance 0

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