INT142829

Context Info Confidence 0.46 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 3.37 Pain Relevance 1.03

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1) nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)

CREB1 (Homo sapiens)

Pain Link Frequency Relevance Heat antidepressant 6 99.92 Desipramine 5 96.56 fluoxetine 1 92.96 cytokine 127 92.56 agonist 51 77.88 Inflammation 141 65.88 Inflammatory response 14 61.56 chemokine 5 52.00 Central nervous system 23 50.00 monoamine 1 38.00

Disease Link Frequency Relevance Heat Stress 18 98.58 Cancer 147 98.44 Breast Cancer 125 96.36 Clear Cell Sarcoma 28 92.96 Dermatofibroma 1 83.92 Bladder Cancer 2 81.60 Skin Cancer 4 80.84 Lymphatic System Cancer 4 79.96 Malignant Neoplastic Disease 8 79.20 Pancreatic Cancer 1 79.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system.

Transcription (transcription) of cyclic AMP-response element-driven gene associated with antidepressant

1) Confidence 0.46 Published 2007 Journal Biochem. Pharmacol. Section Title Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.45

Wang et al [14] found the EWSR1-CREB1 chimeric transcript in 1 of 15 cases (~7%), a superficial tumor in the palm of a 66-year-old female.

Transcription (transcript) of CREB1 associated with cancer

2) Confidence 0.39 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.19 Pain Relevance 0

Mitogen- and stress-activated kinase 1 and 2 (MSK1/2), for example, can directly activate transcription factors such as cAMP-response element-binding protein (CREB), activating transcription factor 1 (ATF1), NF-?

Transcription (transcription) of cAMP-response element-binding protein associated with stress

3) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.16 Pain Relevance 0

Mitogen- and stress-activated kinase 1 and 2 (MSK1/2), for example, can directly activate transcription factors such as cAMP-response element-binding protein (CREB), activating transcription factor 1 (ATF1), NF-?

Transcription (transcription) of CREB associated with stress

4) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.16 Pain Relevance 0

The results suggest that ceramide-induced TLR4 signaling causes rapid phosphorylation/transcription of proteins involved in IRF3 and AP-1 transcription, including CREB, Fyn, PLC?

Transcription (transcription) of CREB

5) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0.03

MAPK can phosphorylate a variety of transcription factors, for example, ATF2, ELK1, CREB, MEF2C, CHOP/GADD153, and C/EBP?

Transcription (transcription) of CREB

6) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.12 Pain Relevance 0.22

Current studies using CGH and cDNA microarray analysis suggest a distinct signature of chromosome gains and losses and gene expression for the different classes of familial breast cancers (BRCA1, BRCA2, and BRCAX) compared to sporadic breast cancers.194 BRCA1 appears to interact with the p53 protein (leading to induction of the cell-cycle inhibitor p21Cip1/WAF1; Fig. 1)195 directly, with the RNA polymerase holoenzyme, with the transcription factor CREB, with two proteins termed BAP1 and BARD1, with ER?

Transcription (transcription) of CREB associated with breast cancer

7) Confidence 0.11 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.20 Pain Relevance 0

are also used by other nuclear transcription factors, including cAMP response element-binding protein (CREB) [88, 89], activator protein-1 (AP-1) [88], basic helix-loop-helix factors [90], signal transducers and activators of transcription (STATs) [91–93], and nuclear factor-?

Transcription (transcription) of cAMP response element-binding protein

8) Confidence 0.10 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.28 Pain Relevance 0.16

are also used by other nuclear transcription factors, including cAMP response element-binding protein (CREB) [88, 89], activator protein-1 (AP-1) [88], basic helix-loop-helix factors [90], signal transducers and activators of transcription (STATs) [91–93], and nuclear factor-?

Transcription (transcription) of CREB

9) Confidence 0.10 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.27 Pain Relevance 0.16

General Comments

This test has worked.