INT142884

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.28

cytosol (TRPV1) transport (TRPV1) signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1) plasma membrane (TRPV1)

IGF1 (Homo sapiens) TRPV1 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 1 88.56 Pain 2 77.40 qutenza 1 71.64 Peripheral nervous system 1 56.88

Disease Link Frequency Relevance Heat Neuroblastoma 2 88.36 Pain 2 77.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By blocking phosphatidylinositol-3-kinase [PI(3)K] or mitogen-activated protein kinase (MAPK) signaling, we concluded that the increase in total TRPV1 protein content induced by IGF-I was controlled by PI(3)K signaling, whereas insulin seemed to regulate TRPV1 protein expression via both PI(3)K and MAPK pathways.

IGF-I Positive_regulation (induced) of TRPV1

1) Confidence 0.04 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17385724 Disease Relevance 0.24 Pain Relevance 0.28

General Comments

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