INT143006

Context Info Confidence 0.73 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 23 Total Number 26 Disease Relevance 22.92 Pain Relevance 0.88

extracellular region (A1BG) molecular_function (A1BG) biological_process (A1BG)

Anatomy Link Frequency pancreas 7 blood 4 liver 3 hip 1 epithelium 1 A1BG (Homo sapiens)

Pain Link Frequency Relevance Heat beta blocker 10 93.20 Pain 10 91.28 metalloproteinase 18 83.80 cva 6 81.64 Chronic pancreatitis 90 80.40 Inflammation 8 5.00 Multiple sclerosis 6 5.00 Central nervous system 5 5.00 Spinal cord 3 5.00 Neuritis 3 5.00

Disease Link Frequency Relevance Heat Ketoacidosis 8 100.00 Liver Cancer 18 99.84 Adenocarcinoma 918 99.28 Cancer 630 99.16 Malignant Neoplastic Disease 54 99.12 Bladder Cancer 18 99.00 Pancreatic Cancer 288 98.80 Disorder Of Lipid Metabolism 23 98.00 Neuromyelitis Optica 81 93.76 Hypertension 46 91.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot analysis demonstrated elevated protein levels of MMP-9, DJ-1 and A1BG in cancerous pancreatic juice compared with cancer-free pancreatic juice, which is consistent with our proteomic findings.

Gene_expression (levels) of A1BG associated with cancer

1) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.51 Pain Relevance 0

We further confirmed the expression levels of three up-regulated proteins (MMP-9, DJ-1 and A1BG) in pancreatic juice, tissue and serum samples using Western blot, IHC or ELISA.

Gene_expression (expression) of A1BG

2) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.28 Pain Relevance 0.16

As seen in Figure 3, compared with cancer-free controls, increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were detected by Western blot.

Gene_expression (expression) of A1BG associated with cancer

3) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.68 Pain Relevance 0

The expressions of MMP-9, DJ-1 and A1BG were confirmed by immunohistochemistry in 51 pancreatic cancer and 8 normal pancreas samples that were not included in the proteomic experiment (Table 4; Figure 4).

Gene_expression (expressions) of A1BG in pancreas associated with pancreatic cancer

4) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.88 Pain Relevance 0

The relationships with DJ-1, MMP-9 and A1BG expression and clinicopathological parameters were analyzed using Chi-square or Fisher's exact tests.

Gene_expression (expression) of A1BG

5) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.33 Pain Relevance 0.06

Western blot analysis of MMP-9, DJ-1 and A1BG

Gene_expression (analysis) of A1BG

6) Confidence 0.63 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.73 Pain Relevance 0

To further investigate this issue, our study prospectively follows 157 consecutive primary total hip arthroplasties using the ABG I prosthesis at an average follow-up of 10 years.

Gene_expression (prosthesis) of ABG I in hip

7) Confidence 0.60 Published 2007 Journal J Arthroplasty Section Abstract Doc Link 17400092 Disease Relevance 0.16 Pain Relevance 0.09

Immunohistochemical study showed MMP-9, DJ-1 and A1BG positively expressed in 82.4%, 72.5% and 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues.

Gene_expression (expressed) of A1BG in pancreas associated with pancreatic cancer

8) Confidence 0.56 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 1.07 Pain Relevance 0.12

Yoon et al. [19] also demonstrated A1BG over-expression in liver cancer cell lines and tissues by semi-quantitative RT-PCR.

Gene_expression (-) of A1BG in liver associated with liver cancer

9) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.35 Pain Relevance 0

Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients Background

Gene_expression (overexpressed) of A1BG associated with adenocarcinoma

10) Confidence 0.56 Published 2008 Journal BMC Cancer Section Title Doc Link PMC2528014 Disease Relevance 0.80 Pain Relevance 0.03

Our immunohistochemical study further validated that A1BG protein over-expression was seen in most PDAC tissues, but not detected in normal pancreas tissues.

Gene_expression (expression) of A1BG in pancreas associated with adenocarcinoma

11) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0

Our immunohistochemical study further validated that A1BG protein over-expression was seen in most PDAC tissues, but not detected in normal pancreas tissues.

Gene_expression (over) of A1BG in pancreas associated with adenocarcinoma

12) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0

Our immunohistochemical study further validated that A1BG protein over-expression was seen in most PDAC tissues, but not detected in normal pancreas tissues.

Gene_expression (-) of A1BG in pancreas associated with adenocarcinoma

13) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0

Using a glycoprotein profiling method, Kreunin et al. [18] recently found that A1BG was detected in urinary samples from bladder cancer patients, but in none of the samples obtained from non-tumor-bearing individuals.

Neg (none) Gene_expression (detected) of A1BG in bladder associated with cancer and bladder cancer

14) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.23 Pain Relevance 0

Yoon et al. [19] also demonstrated A1BG over-expression in liver cancer cell lines and tissues by semi-quantitative RT-PCR.

Gene_expression (expression) of A1BG in liver associated with liver cancer

15) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.36 Pain Relevance 0

Increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were confirmed by Western blot.

Gene_expression (expression) of A1BG

16) Confidence 0.56 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 1.01 Pain Relevance 0.11

Yoon et al. [19] also demonstrated A1BG over-expression in liver cancer cell lines and tissues by semi-quantitative RT-PCR.

Gene_expression (over) of A1BG in liver associated with liver cancer

17) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.35 Pain Relevance 0

It uses ventilator settings and routinely monitored physiological parameters as inputs to produce steady-state estimates of the patient's ABG.

Gene_expression (produce) of ABG

18) Confidence 0.53 Published 2010 Journal Comput Methods Programs Biomed Section Abstract Doc Link 19864039 Disease Relevance 0.32 Pain Relevance 0.12

A1BG was over-expressed in the cytoplasma of malignant epithelia in 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues (p < 0.01).

Gene_expression (expressed) of A1BG in pancreas associated with malignant neoplastic disease and pancreatic cancer

19) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.43 Pain Relevance 0.07

A1BG was over-expressed in the cytoplasma of malignant epithelia in 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues (p < 0.01).

Gene_expression (-) of A1BG in pancreas associated with malignant neoplastic disease and pancreatic cancer

20) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.43 Pain Relevance 0.07

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