INT143162

Context Info Confidence 0.78 First Reported 2006 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 7 Total Number 14 Disease Relevance 5.86 Pain Relevance 0.49

cytosol (S100a6) nuclear envelope (S100a6) plasma membrane (S100a6) nucleus (S100a6) cytoplasm (S100a6)

Anatomy Link Frequency uterus 2 adipocyte 2 epithelial cells 1 S100a6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 12 99.60 Potency 24 5.00 agonist 16 5.00 Dismenorea 8 5.00 antagonist 8 5.00

Disease Link Frequency Relevance Heat Cancer 50 99.84 Pancreatic Cancer 24 99.82 Pancreatitis 30 99.60 Ductal Carcinoma 12 99.48 Malignant Neoplastic Disease 6 95.76 Breast Cancer 8 42.28 Obesity 16 11.56 Hypersensitivity 32 5.00 Dysmenorrhea 8 5.00 Reprotox - General 1 8 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, we measured S100A6 expression in pancreatic tissues and juice to evaluate its involvement in pancreatic carcinogenesis.

Gene_expression (expression) of S100A6

1) Confidence 0.78 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 0.57 Pain Relevance 0

In analyses of pancreatic juice, IPMN and pancreatic cancer samples expressed significantly higher levels of S100A6 than did chronic pancreatitis samples (both; P < 0.017), but levels in pancreatic cancer and IPMN samples did not differ form each other.

Gene_expression (expressed) of S100A6 associated with cancer, pancreatic cancer and chronic pancreatitis

2) Confidence 0.78 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 1.44 Pain Relevance 0.17

The present data suggest that expression of S100A6 is increased in a stepwise manner during pancreatic carcinogenesis and may be a biomarker for evaluating malignant potential.

Gene_expression (expression) of S100A6 associated with malignant neoplastic disease

3) Confidence 0.78 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 1.28 Pain Relevance 0.18

There are few reports describing the diagnostic significance of S100A6 expression in clinical samples obtained from patients with pancreatic disease.

Gene_expression (expression) of S100A6 associated with pancreatitis

4) Confidence 0.78 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 0.36 Pain Relevance 0

Microdissected invasive ductal carcinoma and intraductal papillary mucinous neoplasm (IPMN) cells expressed significantly higher levels of S100A6 than did microdissected pancreatitis-affected epithelial and normal cells (all comparison; P < 0.008).

Gene_expression (expressed) of S100A6 associated with ductal carcinoma, cancer and pancreatitis

5) Confidence 0.78 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 1.05 Pain Relevance 0.06

In addition, treatment with estrogenic compounds resulted in a significant increase in the expression of calcyclin mRNA, whose level paralleled those of oxytocin and Acrp30, as shown in the Additional file 1 and Fig. 3.

Gene_expression (expression) of calcyclin mRNA

6) Confidence 0.65 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

As shown in Fig. 3, the expression level of calcium binding protein A6 (S100a6) in this tissue significantly increased when treated with OP (3.1-fold) and NP (4.2-fold).

Gene_expression (expression) of S100a6

7) Confidence 0.65 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

The effect of E2 on the expression level of calcyclin mRNA in uteri was further examined to elucidate a relationship between expression levels of calcyclin and estrogenic compounds.

Gene_expression (expression) of calcyclin

8) Confidence 0.65 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

The effect of E2 on the expression level of calcyclin mRNA in uteri was further examined to elucidate a relationship between expression levels of calcyclin and estrogenic compounds.

Gene_expression (expression) of calcyclin mRNA

9) Confidence 0.65 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

Median levels of S100A6 in invasive ductal carcinoma were higher than those in IPMN, and those in pancreatitis-affected epithelial cells tended to be higher than those in normal cells, although these differences were not statistically significant.

Gene_expression (levels) of S100A6 in epithelial cells associated with ductal carcinoma, cancer and pancreatitis

10) Confidence 0.60 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 1.16 Pain Relevance 0.07

To investigate the regulation of various genes in the uterus of rats during estrous cycle, the expression levels of CaBP-9k, oxytocin, Acrp30, Ldha, and S100a6 mRNA were analyzed by real-time PCR.

Spec (analyzed) Gene_expression (expression) of S100a6 in uterus

11) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

The expression levels of representative genes, i.e., calbindin-D9k (CaBP-9k; vitamin D-dependent calcium-binding protein), oxytocin, adipocyte complement related protein (MW 30 kDa), lactate dehydrogenase A and calcium binding protein A6 (S100a6; calcyclin), were confirmed in these tissues by real-time PCR.

Gene_expression (expression) of S100a6 in adipocyte

12) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

In addition, the expression patterns of CaBP-9k, oxytocin, Acrp, Ldha, and calcyclin mRNAs were altered in the uterus of immature rats during the estrous cycle.

Gene_expression (expression) of calcyclin in uterus

13) Confidence 0.49 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

The expression levels of representative genes, i.e., calbindin-D9k (CaBP-9k; vitamin D-dependent calcium-binding protein), oxytocin, adipocyte complement related protein (MW 30 kDa), lactate dehydrogenase A and calcium binding protein A6 (S100a6; calcyclin), were confirmed in these tissues by real-time PCR.

Gene_expression (expression) of calcyclin in adipocyte

14) Confidence 0.44 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

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