INT143209

Context Info Confidence 0.18 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.87 Pain Relevance 0.14

mitochondrion (ALDOC) small molecule metabolic process (ALDOC) lyase activity (ALDOC) aging (ALDOC) carbohydrate metabolic process (ALDOC) cytoplasm (ALDOC)

Anatomy Link Frequency plasma 1 ALDOC (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 93.08 alcohol 1 90.96 imagery 6 45.92 abdominal pain 1 35.40 Arthritis 2 32.20 Inflammation 8 31.76

Disease Link Frequency Relevance Heat Death 1 94.52 Neuromuscular Disease 1 94.32 Hypocalcemia 1 94.24 Hemolytic Anemia 1 86.28 Metastasis 1 86.20 Cancer 12 68.88 Thyroid Neoplasm 9 58.00 Myositis 14 57.36 Hashimoto Disease 3 51.32 Polymyositis 22 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The physiological function of TPI is to adjust the rapid equilibrium between dihydroxyacetone phosphate and glyceraldehyde-3-phosphate produced by aldolase in glycolysis, which is interconnected to the pentose phosphate pathway and to lipid metabolism via triosephosphates.

Gene_expression (produced) of aldolase

1) Confidence 0.18 Published 2006 Journal IUBMB Life Section Abstract Doc Link 17424909 Disease Relevance 0.18 Pain Relevance 0.09

At the present admission, laboratory investigation showed a 40-fold elevation of plasma creatine kinase (CK) level, as well as about 5-fold elevation of aldolase, and 3-fold transaminase and lactic dehydrogenase (LDH) levels.

Gene_expression (elevation) of aldolase in plasma

2) Confidence 0.09 Published 2008 Journal Cases J Section Body Doc Link PMC2584084 Disease Relevance 0.69 Pain Relevance 0.05

General Comments

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