INT143466

Context Info Confidence 0.34 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.67 Pain Relevance 0.88

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Anatomy Link Frequency immune cells 1 aorta 1 respiratory 1 Cybb (Rattus norvegicus)

Pain Link Frequency Relevance Heat Rostral ventrolateral medulla 7 98.90 depression 6 96.12 anesthesia 7 87.44 cerebral cortex 2 82.80 Hippocampus 17 81.84 Central nervous system 1 79.52 fibrosis 3 75.80 Inflammation 6 73.12 Pain 1 70.84 ischemia 86 50.00

Disease Link Frequency Relevance Heat Neutrophil Disorders 79 97.76 Stress 34 97.44 Disease 18 97.44 Depression 2 96.12 Heart Rate Under Development 1 91.20 Pressure Volume 2 Under Development 1 90.68 Targeted Disruption 3 90.12 Stroke 9 87.28 Death 26 86.60 Cardiovascular Disorder Under Development 8 80.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies in immune cells have provided evidence that the Rho GTPase, Rac1, plays an important role in NOX2 activation in immune cells.

Positive_regulation (activation) of NOX2 in immune cells

1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.50 Pain Relevance 0.08

Mutations in the gp91phox gene (CYBB on chromosome Xp21.1) cause the X-linked recessive form of the disease that affects the majority of CGD patients (?

Positive_regulation (Mutations) of CYBB associated with disease and neutrophil disorders

2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668749 Disease Relevance 1.00 Pain Relevance 0.18

Further, gp91phox and 3-nitrotyrosine in heart (7, 8), p22phox, Nox-4, and gp91phox in kidney (10), and p22phox in aorta (9) were increased in aldosterone/salt rats.

Positive_regulation (increased) of gp91phox in aorta

3) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.62 Pain Relevance 0.07

This was accompanied by an increase in O2*- production (60-240 min) in the RVLM, alongside phosphorylation of p47(phox) or p67(phox), upregulation of gp91(phox) or p47(phox) protein, and increase in Rac-1 or NADPH oxidase activity (60-120 min), and a depression of mitochondrial respiratory enzyme activity (120-240 min).

Positive_regulation (upregulation) of gp91 in respiratory associated with rostral ventrolateral medulla and depression

4) Confidence 0.01 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17448908 Disease Relevance 0.55 Pain Relevance 0.54

General Comments

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