INT143580

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Trap1) protein folding (Trap1) mitochondrion (Trap1)
response to stress (Trap1)
Anatomy Link Frequency
dorsal root ganglia 1
Trap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 3 100.00 Very High Very High Very High
allodynia 4 78.48 Quite High
Pain 2 25.00 Low Low
Sciatic nerve 1 25.00 Low Low
intrathecal 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 1 99.72 Very High Very High Very High
Necrosis 1 99.40 Very High Very High Very High
Cancer 1 99.22 Very High Very High Very High
Neuropathic Pain 4 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor 1 (TNFR1) in dorsal root ganglia (DRG) and in spinal dorsal horn are upregulated after nerve injury and that many TNF-alpha-containing neurons overexpress TNFR1.
Regulation (upregulated) of TNF receptor 1 in dorsal root ganglia associated with necrosis, nervous system injury, cancer and spinal dorsal horn
1) Confidence 0.16 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.45 Pain Relevance 0.24

General Comments

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