INT1438

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Context Info
Confidence 0.81
First Reported 1977
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 360
Total Number 363
Disease Relevance 101.26
Pain Relevance 116.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
pituitary 51
plasma 12
corticotrophs 12
anterior pituitary 12
brain 8
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2606 100.00 Very High Very High Very High
agonist 1543 100.00 Very High Very High Very High
Opioid 481 100.00 Very High Very High Very High
Neuropeptide 369 100.00 Very High Very High Very High
corticosteroid 290 100.00 Very High Very High Very High
narcan 268 100.00 Very High Very High Very High
Enkephalin 259 100.00 Very High Very High Very High
Morphine 204 100.00 Very High Very High Very High
Endogenous opioid 193 100.00 Very High Very High Very High
Analgesic 68 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 6134 100.00 Very High Very High Very High
Pituitary Cancer 697 99.96 Very High Very High Very High
Adenoma 303 99.96 Very High Very High Very High
Syndrome 151 99.96 Very High Very High Very High
Urological Neuroanatomy 20 99.60 Very High Very High Very High
Endocrine Disease 20 99.58 Very High Very High Very High
Targeted Disruption 2915 99.56 Very High Very High Very High
Pain 203 99.56 Very High Very High Very High
Neuropathic Pain 19 99.56 Very High Very High Very High
Anxiety Disorder 319 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The experiments were based on previous evidence that novel training experiences release hypothalamic beta-endorphin.
Localization (release) of beta-endorphin
1) Confidence 0.81 Published 1985 Journal Behav. Neural Biol. Section Abstract Doc Link 4062777 Disease Relevance 0 Pain Relevance 0.12
Treatment known to enhance (metyrapone pretreatment), reduce (2% saline in the drinking water) or block (dexamethasone pretreatment) the release of beta-endorphin from the anterior pituitary did not affect the display of analgesia in defeated mice.
Localization (release) of beta-endorphin in anterior pituitary associated with dexamethasone and analgesia
2) Confidence 0.81 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2966409 Disease Relevance 0 Pain Relevance 1.19
Beta-endorphin is an endogenous opioid peptide that is released during stress and has been associated with many physiological functions.
Localization (released) of Beta-endorphin associated with stress and endogenous opioid
3) Confidence 0.81 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834911 Disease Relevance 0.32 Pain Relevance 0.10
The purpose of this study was to determine the timing of the release of beta-endorphin (BE), a possible biomarker, after exposure to pain and/or handling stress in order to standardize measurements.
Localization (release) of beta-endorphin associated with stress and pain
4) Confidence 0.81 Published 2009 Journal J. Neurosci. Methods Section Abstract Doc Link 19007812 Disease Relevance 0.27 Pain Relevance 0.39
The serum level of corticosterone was also increased (P < 0.01) at the time of beta-endorphin release.
Localization (release) of beta-endorphin
5) Confidence 0.81 Published 1998 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 9773504 Disease Relevance 0.60 Pain Relevance 0.89
Because the opioid peptide beta-endorphin is co-synthesized and released with melanocortins from proopiomelanocortin (POMC) neuronal terminals, we examined the physiological role of beta-endorphin in feeding and energy homeostasis using a strain of mutant mice with a selective deficiency of beta-endorphin.
Localization (released) of beta-endorphin in neuronal associated with sprains and strains and opioid
6) Confidence 0.81 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12851316 Disease Relevance 0.24 Pain Relevance 0.19
In the appetitive phase, beta-endorphin release increases the incentive value of food as a primary reinforcer.
Localization (release) of beta-endorphin
7) Confidence 0.81 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12851316 Disease Relevance 0.05 Pain Relevance 0.14
Long-term effects were determined by exposing the cells to ketamine, allowing the cells to recover overnight, then stimulating the secretion of beta-endorphin.
Localization (secretion) of beta-endorphin
8) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Body Doc Link 12567337 Disease Relevance 0 Pain Relevance 0
AtT-20 cells were stimulated with secretagogues to induce secretion of beta-endorphin.
Localization (secretion) of beta-endorphin in AtT-20
9) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Body Doc Link 12567337 Disease Relevance 0 Pain Relevance 0
Secretion of beta-endorphin was determined by enzyme-linked immunosorbent assay.
Localization (Secretion) of beta-endorphin
10) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Body Doc Link 12567337 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Clinically relevant concentrations of ketamine stimulated both immediate and delayed secretion of beta-endorphin.
Localization (secretion) of beta-endorphin
11) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Body Doc Link 12567337 Disease Relevance 0 Pain Relevance 0
We hypothesized that ketamine would also alter secretion of beta-endorphin.
Localization (secretion) of beta-endorphin
12) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Abstract Doc Link 12567337 Disease Relevance 0.09 Pain Relevance 0.36
Stimulation of beta-endorphin secretion by ketamine persisted into the subsequent day.
Localization (secretion) of beta-endorphin
13) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Body Doc Link 12567337 Disease Relevance 0 Pain Relevance 0
RESULTS: Ketamine increased secretion of beta-endorphin to levels that were up to 3 times greater than baseline secretion.
Localization (secretion) of beta-endorphin
14) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Body Doc Link 12567337 Disease Relevance 0 Pain Relevance 0
Propofol inhibits in vitro secretion of beta-endorphin from a mouse pituitary cell line (AtT-20).
Localization (secretion) of beta-endorphin in AtT-20
15) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Abstract Doc Link 12567337 Disease Relevance 0.10 Pain Relevance 0.38
Ketamine stimulates secretion of beta-endorphin from a mouse pituitary cell line.
Localization (secretion) of beta-endorphin in pituitary associated with ketamine
16) Confidence 0.80 Published 2003 Journal Reg Anesth Pain Med Section Title Doc Link 12567337 Disease Relevance 0.10 Pain Relevance 0.39
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
Localization (secretion) of ACTH
17) Confidence 0.80 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
Effect of S(-)- and R(+)-salsolinol on the POMC gene expression and ACTH release of an anterior pituitary cell line.
Localization (release) of ACTH in anterior pituitary
18) Confidence 0.80 Published 1995 Journal Alcohol Section Title Doc Link 8519440 Disease Relevance 0.17 Pain Relevance 0.33
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
Localization (released) of ACTH
19) Confidence 0.80 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.17 Pain Relevance 0.31
It is also suggested that the excessive beta-endorphin may be secreted by T-lymphocytes and possibly macrophages involved in the cell-mediated immune response (CMIR) to the ova.
Localization (secreted) of beta-endorphin in T-lymphocytes
20) Confidence 0.80 Published 1989 Journal Comp Biochem Physiol A Comp Physiol Section Abstract Doc Link 2571452 Disease Relevance 0.24 Pain Relevance 0.36

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