INT143850

Context Info Confidence 0.73 First Reported 2004 Last Reported 2010 Negated 3 Speculated 1 Reported most in Body Documents 19 Total Number 25 Disease Relevance 9.52 Pain Relevance 1.54

nucleus (S100a1) cytoplasm (S100a1)

Anatomy Link Frequency neutrophils 3 macrophages 2 aggregate cell 1 dendritic cells 1 cleft 1 S100a1 (Mus musculus) S100a1 - S100A (6)

Pain Link Frequency Relevance Heat Inflammation 808 99.56 cytokine 228 98.64 Pain 12 91.72 Arthritis 20 89.64 rheumatoid arthritis 10 80.12 pain flank 1 73.68 corticosteroid 12 68.48 Inflammatory stimuli 10 64.48 imagery 15 58.88 Sciatic nerve 1 36.08

Disease Link Frequency Relevance Heat Cancer 416 99.86 INFLAMMATION 842 99.56 Hyperplasia 35 98.36 Langerhans-cell Histiocytosis 6 98.32 Adenoid Cystic Carcinoma 3 98.08 Rhinitis 1 96.04 Wound Healing 16 95.48 Diabetes Insipidus 1 93.60 Papular Skin Disease 1 93.36 Stress 322 90.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Up</span>regulation of S100A gene expression in corneas upon CorNV induction

Gene_expression (expression) of S100A gene (S100A) in corneas

1) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.09 Pain Relevance 0

The RT-QPCR assay of S100A gene expression in the S-CorNV model revealed that the changes of all S100A genes manifested in a similar time-dependent manner, peaking around day 5 for all genes (Table 3).

Gene_expression (expression) of S100A gene (S100A)

2) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.07 Pain Relevance 0

The dimers of interest in studies concerning cerebral events are those containing S100B (S100BB and S100A1B).

Gene_expression (containing) of S100A

3) Confidence 0.65 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.35 Pain Relevance 0

This implies that neutrophils are the main sources of S100A and other inflammatory molecules in S-CorNV.

Gene_expression (sources) of S100A (S100A) in neutrophils associated with inflammation

4) Confidence 0.64 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.13

Apart from the S100A proteins, representative pro-inflammatory cytokines (IL-1?

Gene_expression (proteins) of S100A (S100A) associated with inflammation and cytokine

5) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.19 Pain Relevance 0.15

S100A proteins are reportedly produced mainly by macrophages and neutrophils, the two main cell types that infiltrated the corneas in CorNV models [3-5].

Gene_expression (produced) of S100A (S100A) in macrophages

6) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.15 Pain Relevance 0.08

We also considered the possibility that some wild-type TSCs might survive the transplantation to B6.EGFP mice and express S100 but not EGFP.

Neg (not) Gene_expression (express) of S100

7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.13 Pain Relevance 0

S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].

Gene_expression (expressed) of S100 in macrophages

8) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0

An iliac crest bone biopsy showed an eosinophil-rich infiltrate admixed with histiocytoid cells with reniform nuclei, which expressed S100 and CD1a, consistent with a diagnosis of LCH.

Gene_expression (expressed) of S100 in crest associated with langerhans-cell histiocytosis

9) Confidence 0.34 Published 2008 Journal J. Cutan. Pathol. Section Abstract Doc Link 18840155 Disease Relevance 1.04 Pain Relevance 0.09

They include the High Mobility Group family proteins including the prototypic HMGB1/amphoterin, members of the S100/calgranulin protein family, matrix proteins such as Collagen I and IV, A?

Gene_expression (members) of S100

10) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.02 Pain Relevance 0.11

S100 proteins have wildly varying expression patterns (Table 3).

Gene_expression (expression) of S100

11) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.19 Pain Relevance 0

Possible ligands of RAGE: S100A1, S100A8/9

Gene_expression (/) of S100A1

12) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.06 Pain Relevance 0

They include the High Mobility Group family proteins including the prototypic HMGB1/amphoterin, members of the S100/calgranulin protein family, matrix proteins such as Collagen I and IV, A?

Gene_expression (/) of S100

13) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.02 Pain Relevance 0.11

S100A1 is present in the cytoplasm and nucleus – rat heart muscle cell line H9c2 is mostly nuclear, adult skeletal muscle mostly cytoplasmic.

Gene_expression (present) of S100A1 in heart muscle cell

14) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.08 Pain Relevance 0.03

There are several important questions that need to be addressed when examining proposed S100-RAGE interactions: Does this interaction occur in vivo in addition to in vitro?

Spec (examining) Gene_expression (examining) of S100

15) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.98 Pain Relevance 0.29

S100A proteins are reportedly produced mainly by macrophages and neutrophils, the two main cell types that infiltrated the corneas in CorNV models [3-5].

Gene_expression (produced) of S100A (S100A) in neutrophils

16) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.15 Pain Relevance 0.08

Immunohistochemically, the tumor cells express low-molecular-weight keratins, carcinoembryonic antigen, lysozyme, alpha1-antichymotrypsin, S100, and type IV collagen.

Gene_expression (express) of S100 associated with cancer

17) Confidence 0.15 Published 2007 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17488169 Disease Relevance 1.19 Pain Relevance 0.08

S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].

Gene_expression (expressed) of S100 in dendritic cells

18) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0

S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].

Gene_expression (expressed) of S100 in neutrophils

19) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0

S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].

Gene_expression (expressed) of S100 in lymphocytes

20) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0

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