INT143974

Context Info Confidence 0.17 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0.20

signal transduction (Chrna7) Golgi apparatus (Vti1b) plasma membrane (Chrna7) cytoplasm (Chrna7)

Anatomy Link Frequency cholinergic neurons 1 Chrna7 (Rattus norvegicus) Vti1b (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 1 89.12 substance P 1 88.24 Calcitonin gene-related peptide 1 86.96 Pain 1 70.16 Analgesic 1 25.00

Disease Link Frequency Relevance Heat Clostridium Infection 1 100.00 Strabismus 1 62.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Botulinum toxin (BTX), derived from the exotoxin of Clostridium botulinum, cleaves Soluble N-ethylmaleimide-sensitive factor-Attachment protein REceptor (SNARE) proteins, causing chemodenervation of cholinergic neurons.

BTX Positive_regulation (cleaves) of N-ethylmaleimide-sensitive factor-Attachment protein REceptor in cholinergic neurons associated with clostridium infection

1) Confidence 0.17 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 17499937 Disease Relevance 0.16 Pain Relevance 0.20

General Comments

This test has worked.