INT14405

Context Info Confidence 0.65 First Reported 1987 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 14 Total Number 22 Disease Relevance 3.00 Pain Relevance 1.64

extracellular space (SERPINF2) extracellular region (SERPINF2)

Anatomy Link Frequency plasma 1 platelets 1 urine 1 neutrophil 1 SERPINF2 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 16 100.00 Catecholamine 6 99.20 Inflammatory response 4 96.72 Angina 1 95.96 cva 2 92.72 anesthesia 13 88.96 Pain 8 86.12 headache 1 76.20 Dopamine 19 55.04 aspirin 12 50.00

Disease Link Frequency Relevance Heat Injury 16 99.26 Anaemia 1 97.84 Toxicity 5 97.44 INFLAMMATION 12 96.36 Angina 1 95.96 Hepatotoxicity 1 94.60 Renal Failure 1 94.08 Cv General 3 Under Development 2 92.72 Myocardial Infarction 2 92.12 Hematuria 1 89.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Serial determinations of total FDP, FDP D-Dimer (specific for FbDP), fibrinogen (Fg), PT, APTT, reptilase time (RT), plasminogen, alpha 2-antiplasmin (AAP), euglobulin lysis time (ELT) and antithrombin III (ATIII) were performed before and 1, 2, 4, 6, 12, 24, 48 hr after initiation of tPA injection in the 29 patients in order to evaluate the hemostatic changes after thrombolytic therapy.

Spec (determinations) Gene_expression (determinations) of AAP

1) Confidence 0.65 Published 1990 Journal Thromb. Res. Section Abstract Doc Link 1693793 Disease Relevance 0.26 Pain Relevance 0.10

CONCLUSIONS: The use of aspirin/NSAIDS and anticoagulants was associated with a trend for increased sensitivity with no change in specificity for the detection of AAP/CRC.

Gene_expression (detection) of AAP

2) Confidence 0.65 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19293792 Disease Relevance 0 Pain Relevance 0

At the threshold of 75 ng/ml for positivity, the specificity for the detection of AAP/CRC was 89.5% for aspirin/NSAIDS use vs. 91.2% for nondrug takers (P=0.47), and at the threshold of 100 ng/ml, the specificity was 92.17 vs. 93.0% (P=0.69).

Gene_expression (detection) of AAP

3) Confidence 0.65 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19293792 Disease Relevance 0.05 Pain Relevance 0

At the threshold 75 ng/ml for positivity, the sensitivity for the detection of AAP/CRC was 66.7% for aspirin/NSAIDS use vs. 51.2% for nondrug takers (P=0.20), and at the threshold of 100 ng/ml, the sensitivity was 66.7 vs. 46.5% (P=0.09).

Gene_expression (detection) of AAP

4) Confidence 0.65 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19293792 Disease Relevance 0.07 Pain Relevance 0

Qualitative analysis for the detection of AAP/CRC reveals a trend for an increased sensitivity with aspirin/NSAIDS use.

Gene_expression (detection) of AAP

5) Confidence 0.65 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19293792 Disease Relevance 0.07 Pain Relevance 0

Passing in the ID of the pathway, the API will return all the interactions within the pathway. http://www.pathwayapi.com/api/API_GetPathwayInteractions.php?

Gene_expression (/) of API

6) Confidence 0.65 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0

Seven studies in volunteers are not directly relevant to clinical practice but do raise the issue of whether it is important to apply sensitive measures of renal function and/or injury such as urine concentrations and/or excretion of NAG, beta 2M, alpha 1M, AAP, alpha GST, pi GST, gamma GTP, albumin, protein, and glucose and Cr clearance.

Gene_expression (excretion) of AAP in urine associated with injury

7) Confidence 0.65 Published 1998 Journal J Clin Anesth Section Abstract Doc Link 9805692 Disease Relevance 0.40 Pain Relevance 0.25

Passing in the ID of the pathway, the API will return all the interactions within the pathway. http://www.pathwayapi.com/api/API_GetPathwayInteractions.php?

Gene_expression (/) of api

8) Confidence 0.59 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0

The API call to obtain all the pathways for homo sapiens is:

Gene_expression (obtain) of API

9) Confidence 0.52 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.06

The API call to obtain all the pathways for homo sapiens is:

Gene_expression (call) of API

10) Confidence 0.52 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.05

The API consists of the following modules: + Pathway Formalization: Key features within pathways + Database Cache: How we store, extract and update the data + API Implementation: Short specification of the API Pathway Formalization: Key features within pathways

Gene_expression (The) of API

11) Confidence 0.52 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0

The API consists of the following modules: + Pathway Formalization: Key features within pathways + Database Cache: How we store, extract and update the data + API Implementation: Short specification of the API Pathway Formalization: Key features within pathways

Gene_expression (consists) of API

12) Confidence 0.52 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0

To ensure fast responsiveness, API connections are made towards a central unified database which keeps a cached copy of the records of the other databases.

Gene_expression (connections) of API

13) Confidence 0.52 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0

The AAP activating enzymes were active for at least 21 days and their activity was maintained during at least four repeated cycles of exposure to AAP.

Gene_expression (active) of AAP associated with paracetamol

14) Confidence 0.50 Published 2007 Journal ALTEX Section Abstract Doc Link 17361319 Disease Relevance 0.09 Pain Relevance 0.86

Human neutrophil elastase complexed to alpha 1-antitrypsin was increased in the patient's plasma, while the levels of the complexes thrombin-antithrombinIII and plasmin-alpha 2-antiplasmin, indicating recent coagulation or fibrinolysis, respectively, were not elevated.

Gene_expression (levels) of plasmin-alpha 2-antiplasmin in neutrophil

15) Confidence 0.27 Published 1989 Journal Toxicology Section Abstract Doc Link 2469140 Disease Relevance 0.70 Pain Relevance 0.08

Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged.

Neg (unchanged) Gene_expression (levels) of 2-antiplasmin in plasma

16) Confidence 0.15 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0

AggR regulates the expression of a secreted low-molecular weight protein known as dispersin (aap) which has been identified in 80% of EAEC isolates from one laboratory [54].

Gene_expression (expression) of aap

17) Confidence 0.15 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.52 Pain Relevance 0.05

FP, albumin, CK18, CK19 and API was analyzed using specific primers (Table 2).

Spec (analyzed) Gene_expression (analyzed) of API

18) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0

By applying identical conditions to pMSC, we observed albumin and API expression in 5 out of 8 independent experiments.

Gene_expression (expression) of API

19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0

In these conditions, aMSC expressed albumin and alpha 1 anti-trypsin (API) in 2 of 10 independent experiments, and this exclusively in conditions in which hepatogenic differentiation medium were present (Fig. 3B).

Gene_expression (expressed) of API

20) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.