INT14413

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2002
Negated 3
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.71
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
smooth muscle 2
striatum 2
trachea 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 99.84 Very High Very High Very High
Dopamine 8 98.72 Very High Very High Very High
potassium channel 4 98.52 Very High Very High Very High
agonist 1 98.36 Very High Very High Very High
Angina 3 93.28 High High
noradrenaline 1 92.40 High High
Calcitonin gene-related peptide 5 86.20 High High
adenocard 1 83.12 Quite High
tolerance 1 79.68 Quite High
cerebral cortex 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 99.58 Very High Very High Very High
Hypotension 1 96.16 Very High Very High Very High
Myocardial Infarction 1 94.56 High High
Cv General 3 Under Development 3 93.28 High High
Heart Rate Under Development 1 91.60 High High
Hypersensitivity 1 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of nitrite observed in the presence of L-cysteine suggest that nitrosothiols are not responsible for nitrite-evoked activation of guanylate cyclase.
Neg (not) Regulation (responsible) of Positive_regulation (activation) of guanylate cyclase
1) Confidence 0.62 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10100881 Disease Relevance 0 Pain Relevance 0.09
A plausible hypothesis of the mechanism of nitrate-induced vasodilation has been presented, involving production of nitrosothiols and activation of guanylate cyclase in the vascular smooth muscle.
Regulation (involving) of Positive_regulation (activation) of guanylate cyclase in smooth muscle associated with increased venous pressure under development
2) Confidence 0.43 Published 1985 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 3923783 Disease Relevance 0.53 Pain Relevance 0.29
In the present study, we have applied the brain microdialysis technique to investigate the effect of the stimulation of adenylate cyclase on the extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum of freely moving rats.
Spec (investigate) Regulation (effect) of Spec (investigate) Positive_regulation (stimulation) of cyclase in striatum associated with dopamine
3) Confidence 0.29 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1693944 Disease Relevance 0 Pain Relevance 0.28
The nitrite-elicited relaxation depends on activation of guanylate cyclase and high conductance Ca2+-activated potassium channels; however, activation of potassium channels might be a part of or might act in parallel with the mechanism involving the cyclic GMP system.
Regulation (depends) of Positive_regulation (activation) of guanylate cyclase associated with potassium channel
4) Confidence 0.27 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10100881 Disease Relevance 0 Pain Relevance 0.16
These results suggest that GTP regulation of binding and stimulation of adenylate cyclase occur by fundamentally different mechanisms.
Regulation (regulation) of Positive_regulation (stimulation) of cyclase
5) Confidence 0.04 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319864 Disease Relevance 0 Pain Relevance 0.12
The inhibitory effect of carbachol upon forskolin-stimulated adenylate cyclase was not affected by raising the [K+] from 6 to 18 mM.
Neg (not) Regulation (affected) of Positive_regulation (forskolin-stimulated) of cyclase
6) Confidence 0.03 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2155122 Disease Relevance 0 Pain Relevance 0.12
Neither adenylate cyclase activation nor binding site characteristics were affected by capsaicin-induced denervation.
Neg (Neither) Regulation (affected) of Neg (nor) Positive_regulation (activation) of cyclase associated with qutenza
7) Confidence 0.03 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8387220 Disease Relevance 0.17 Pain Relevance 0.59
Collectively, these results support the notion that the propolis extract-mediated relaxation in the guinea-pig trachea involves the release of nitric oxide, probably from sensory neurons, besides the activation of soluble guanylate cyclase and activation of Ca2+- and ATP-sensitive K+ channels.
Regulation (involves) of Positive_regulation (activation) of guanylate cyclase in trachea
8) Confidence 0.02 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12079001 Disease Relevance 0 Pain Relevance 0.12

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