INT144364

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 3.35
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
brain 1
adult brain 1
Pet1 1
Lmx1b (Mus musculus)
Pain Link Frequency Relevance Heat
tricyclic antidepressant 1 99.32 Very High Very High Very High
sNRI 2 98.68 Very High Very High Very High
Serotonin 20 97.84 Very High Very High Very High
sSRI 3 97.60 Very High Very High Very High
Lasting pain 2 96.48 Very High Very High Very High
antidepressant 4 96.32 Very High Very High Very High
Analgesic 7 95.66 Very High Very High Very High
Raphe 96 93.80 High High
Neurotransmitter 12 92.24 High High
Duloxetine 1 91.68 High High
Disease Link Frequency Relevance Heat
Syndrome 118 99.02 Very High Very High Very High
Ocular Hypertension 94 98.30 Very High Very High Very High
Pain 11 95.60 Very High Very High Very High
Glaucoma 56 93.44 High High
Open-angle Glaucoma 34 91.24 High High
Inflammatory Pain 3 88.44 High High
Renal Disease 8 86.20 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 84.56 Quite High
Disease 6 81.28 Quite High
Targeted Disruption 29 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While it is formally possible that all of the tabulated SSTFs are regulated in all green cells, it is known that Foxd3 and Isl1 are upregulated, and Pax2 and Lmx1b are downregulated, in different populations [9].
Negative_regulation (downregulated) of Lmx1b
1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
We first used Lmx1b antibody [17] to examine whether Lmx1b is deleted in Lmx1b iCKO mice.
Spec (whether) Negative_regulation (deleted) of Lmx1b
2) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.07
As we showed in the present study, the inactivation of Lmx1b in adulthood led to a reduction in central 5-HT levels, probably as a consequence of Tph2 down-regulation.
Negative_regulation (inactivation) of Lmx1b
3) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.07
The number of cells with intense in situ signals was significantly decreased in Lmx1b iCKO relative to wild-type mice (Figure 6).
Negative_regulation (decreased) of Lmx1b
4) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.09
It has been shown that Pet1 is required for terminal differentiation of 5-HTergic neurons during embryonic development [4], and its expression is lost in Lmx1b null mice [12].
Negative_regulation (lost) of Lmx1b in Pet1
5) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.14
To further investigate whether the content of 5-HT in the brain is altered or not, we used HPLC to measure the levels of 5-HT and its metabolite 5-HIAA in the brain, and found that they were decreased in Lmx1b iCKO mice to about 60% and 30% of control levels, respectively (Figure 3E).
Negative_regulation (decreased) of Lmx1b in brain
6) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.04
Nevertheless, these results indicate that deleting Lmx1b in the adult brain impairs Tph2 expression, leading to a deficiency of central 5-HT.
Negative_regulation (deleting) of Lmx1b in adult brain
7) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
OHT was not present in unaffected individuals, and it seems to be a genuine pleiotropic effect of the LMX1B mutation in this family.
Negative_regulation (effect) of LMX1B associated with ocular hypertension
8) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.83 Pain Relevance 0
Furthermore, transfection studies performed with NPS mutants showed no significant dominant-negative effect on the function of the wild-type LMX1B [21,26].
Negative_regulation (effect) of LMX1B associated with syndrome
9) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.80 Pain Relevance 0
Importantly, the analgesic effect of several antidepressant drugs, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants, was either abolished or greatly attenuated in Lmx1b(f/f/p) mice.
Negative_regulation (attenuated) of Lmx1b associated with antidepressant, analgesic, tricyclic antidepressant, snri, serotonin and ssri
10) Confidence 0.37 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17537976 Disease Relevance 0.64 Pain Relevance 1.61

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