INT144429

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.05
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
acinar cell 2
fat 1
kidney 1
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 93.28 High High
Inflammation 23 92.88 High High
chemokine 15 76.16 Quite High
Inflammatory response 4 75.00 Quite High
ischemia 5 73.28 Quite High
imagery 67 69.48 Quite High
Chronic pancreatitis 7 69.40 Quite High
fibrosis 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 5 100.00 Very High Very High Very High
Cancer 136 99.96 Very High Very High Very High
Disease 27 99.66 Very High Very High Very High
Adenocarcinoma 100 98.42 Very High Very High Very High
Targeted Disruption 11 98.26 Very High Very High Very High
Pancreatic Cancer 80 97.28 Very High Very High Very High
INFLAMMATION 26 92.88 High High
Insulin Resistance 7 89.32 High High
Metastasis 12 84.56 Quite High
Injury 30 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lack of p16 did not rescue the angiogenic defect of irradiated rings (data not shown), consistent with the absence of induction of P16 protein in irradiated HUVEC.
Positive_regulation (induction) of P16
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.13 Pain Relevance 0
Therefore, we elected to exploit a series of related genetically engineered mouse models of PDAC that harbor the signature gene mutations of the human disease, including Kras activation and deletion of the p53 or Ink4a/Arf tumor suppressors [11,12].
Positive_regulation (activation) of Ink4a/Arf associated with adenocarcinoma, cancer and disease
2) Confidence 0.49 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 1.33 Pain Relevance 0.09
At later timepoints, some mice showed focal areas of acinar cell damage with upregulated mRNA levels for Cyclin D1 and p16(INK4a).
Positive_regulation (upregulated) of INK4a in acinar cell
3) Confidence 0.27 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.56 Pain Relevance 0.26
At later timepoints, some mice showed focal areas of acinar cell damage with upregulated mRNA levels for Cyclin D1 and p16(INK4a).
Positive_regulation (upregulated) of p16 in acinar cell
4) Confidence 0.27 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.56 Pain Relevance 0.26
High fat diet activated important for cell cycle cyclin-dependent kinase inhibitors p53, p21, p16, and Ywhag.
Positive_regulation (activated) of p16 in fat
5) Confidence 0.14 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.23 Pain Relevance 0
The inactivation of the p16 gene on chromosome 9p21 is another essential genetic alteration in pancreatic cancer [15].
Positive_regulation (inactivation) of p16 associated with pancreatic cancer
6) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.56 Pain Relevance 0
MSCs from GFP+ transgenic mice injected intravenously were reported to home to the kidney of mice with glycerol-induced ARF, but not in normal mice.
Neg (not) Positive_regulation (induced) of ARF in kidney associated with targeted disruption and acute renal failure
7) Confidence 0.03 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.70 Pain Relevance 0.17

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