INT144623

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.60
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2) nucleus (Nfe2l2) DNA binding (Nfe2l2)
cytoplasm (Nfe2l2)
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 11 97.96 Very High Very High Very High
Paracetamol 22 93.80 High High
fibrosis 1 93.36 High High
Inflammation 6 85.16 High High
cINOD 5 80.84 Quite High
Inflammatory response 8 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 77 100.00 Very High Very High Very High
Targeted Disruption 32 100.00 Very High Very High Very High
Apoptosis 13 98.88 Very High Very High Very High
Cancer 8 96.20 Very High Very High Very High
Stress 119 95.56 Very High Very High Very High
Injury 22 95.00 High High
Cirrhosis 1 93.84 High High
Gallstones 1 92.56 High High
Aberrant Crypt Foci 1 89.36 High High
INFLAMMATION 16 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in basal Nrf2 protein expression may explain the reverse in DNCB toxicity protection and the reduction of basal GSH by Keap1 depletion.
Negative_regulation (decrease) of Gene_expression (expression) of Nrf2 protein associated with toxicity
1) Confidence 0.47 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.47 Pain Relevance 0
In summary, this study has identified a panel of Nrf2-dependent hepatic proteins that is statistically robust and demonstrated both decreased and enhanced expression in the absence of the Nrf2 gene.
Negative_regulation (decreased) of Gene_expression (expression) of Nrf2
2) Confidence 0.43 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0 Pain Relevance 0
The higher sensitivity of Nrf2 knockout mice to chemical toxicity is due in part to reduced basal and inducible expression of detoxification enzymes.
Negative_regulation (reduced) of Gene_expression (expression) of Nrf2 associated with targeted disruption and toxicity
3) Confidence 0.43 Published 2007 Journal Toxicol Pathol Section Abstract Doc Link 17562481 Disease Relevance 1.16 Pain Relevance 0.14
Conversely, decreased Nrf2 protein expression resulted in an increased susceptibility to DNCB toxicity.
Negative_regulation (decreased) of Gene_expression (expression) of Nrf2 protein associated with toxicity
4) Confidence 0.35 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.37 Pain Relevance 0
Are CRIF1 and KEAP1 negative regulations of NRF2 completely independent of one another?
Negative_regulation (regulations) of Neg (negative) Gene_expression (negative) of NRF2
5) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.15 Pain Relevance 0
Therefore, our data suggest that modulation of p65 has an effect on the ability of the cell to defend against toxicity via the Nrf2/Keap1 pathway, and that the Nrf2 and NF-?
Negative_regulation (defend) of Gene_expression (pathway) of Nrf2 associated with toxicity
6) Confidence 0.34 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.48 Pain Relevance 0
In line with this we have shown that the expression of Nrf2 was reduced by the co-depletion of Keap1 and p65 (Fig. 7).
Negative_regulation (reduced) of Gene_expression (expression) of Nrf2
7) Confidence 0.34 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.48 Pain Relevance 0
Prior exposure of cells to N-acetyl-L -cysteine blocked not only the ROS production but also the nuclear translocation of Nrf2 and its ARE binding, as well as HO-1 induction by capsaicin.
Negative_regulation (blocked) of Gene_expression (production) of Nrf2 associated with qutenza
8) Confidence 0.15 Published 2007 Journal Antioxid. Redox Signal. Section Abstract Doc Link 17979524 Disease Relevance 0 Pain Relevance 0.66
Eupatilin-induced HO-1 expression and Nrf2 were partly attenuated by MEK inhibitor PD98059 and almost completely by phosphatidyl-inactiol 3 kinase (PI3K) inhibitor LY294002, but not by c-Jun N-terminal kinase (JNK) inhibitor SP600125 or p38 mitogen activated protein kinase (MAPK) inhibitor SB202190.
Negative_regulation (attenuated) of Gene_expression (expression) of Nrf2
9) Confidence 0.11 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19336889 Disease Relevance 0.35 Pain Relevance 0.29
We also found that PD98059, a MEK (MAPK/ERK kinase) inhibitor, attenuated the eupatilin-induced HO-1 expression and nuclear translocation of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2).
Negative_regulation (attenuated) of Gene_expression (expression) of Nrf2
10) Confidence 0.10 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18440740 Disease Relevance 0.14 Pain Relevance 0.07

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