INT144767

Context Info Confidence 0.65 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 1.78 Pain Relevance 1.04

cell proliferation (UCN2) extracellular space (UCN2) extracellular region (UCN2) response to stress (UCN2)

Anatomy Link Frequency sympathetic nervous system 1 UCN2 (Homo sapiens)

Pain Link Frequency Relevance Heat intrathecal 2 99.14 Pain 8 98.92 antagonist 6 93.12 gABA 1 92.56 depression 2 86.76 imagery 2 77.76 GABAergic 2 75.00 Action potential 1 72.28 anesthesia 1 25.00 Visceral pain 1 25.00

Disease Link Frequency Relevance Heat Pain 7 98.92 Stress 7 91.52 Anxiety Disorder 2 87.08 Depression 2 86.76 Hemorrhage 3 76.44 Disease 6 75.00 Stress Incontinence 5 75.00 Overactive Bladder 1 69.84 Apoptosis 16 59.32 Chronic Periodontitis 1 54.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If need be, they will then apply some pain control medication or anesthetic for patients during probing and SRP.

Gene_expression (probing) of SRP associated with pain

1) Confidence 0.65 Published 2007 Journal Clin Oral Investig Section Abstract Doc Link 17576606 Disease Relevance 0.75 Pain Relevance 0.49

Intrathecal NMDA (100 microM, 10 microl) reversed the abolition on SRP caused by anal stretch.

Gene_expression (abolition) of SRP associated with intrathecal

2) Confidence 0.65 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18632795 Disease Relevance 0.34 Pain Relevance 0.42

Nevertheless, a link between anisotropy and spatial relationship sensibility is supported by their positive correlation as shown in Fig.(4, left),so that the more SRP worsens, the more it is imbalanced.

Gene_expression (worsens) of SRP

3) Confidence 0.21 Published 2010 Journal The Open Ophthalmology Journal Section Body Doc Link PMC2928889 Disease Relevance 0 Pain Relevance 0

g/ml) to human SRP72 epitope mapping near the C terminus of SRP72 of human origin (Santa Cruz Biotechnology, 1:2500), human SRP54 (Sigma) (1:2500), which represents the nonphosphorylated SRP protein and human GAPDH (Syd Labs, Boston) (1:3000).

Gene_expression (represents) of SRP

4) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0.04

SRP72 is a constitutive protein present in all eukaryotic organisms that is essential for survival; it is the unique organism that can survive after deletion of this SRP72 protein or other polypeptides of the SRP complex such as Saccharomyces cerevisiae (23), which demonstrates the importance of this protein inside the cellular mechanisms, mainly the translocation of secreted proteins.

Gene_expression (deletion) of SRP

5) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.06 Pain Relevance 0

The characterization of the 41 amino-acid CRF and other peptide members of the mammalian CRF family, urocortin 1, urocortin 2, and urocortin 3, and the cloning of CRF(1) and CRF(2) receptors, which display distinct affinity for CRF ligands, combined with the development of selective CRF receptor antagonists enable us to unravel the importance of CRF(1) receptor in the stress-related endocrine (activation of pituitary-adrenal axis), behavioral (anxiety/depression, altered feeding), autonomic (activation of sympathetic nervous system), and immune responses.

Gene_expression (members) of urocortin 2 in sympathetic nervous system associated with stress, depression, antagonist and anxiety disorder

6) Confidence 0.01 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19120089 Disease Relevance 0.63 Pain Relevance 0.09

General Comments

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