INT14479

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.83
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
blood 1
sputum 1
eosinophils 1
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 99.90 Very High Very High Very High
visual analogue scale 10 99.72 Very High Very High Very High
insula 1 89.52 High High
Inflammatory mediators 6 83.20 Quite High
Codeine 2 75.28 Quite High
Fibrositis 37 67.44 Quite High
Gabapentin 24 60.60 Quite High
Inflammation 288 55.80 Quite High
cytokine 273 48.00 Quite Low
headache 1 34.36 Quite Low
Disease Link Frequency Relevance Heat
Pain 20 99.90 Very High Very High Very High
Asthma 945 96.52 Very High Very High Very High
Cough 3 96.12 Very High Very High Very High
Adhesions 12 85.36 High High
Cognitive Disorder 2 84.96 Quite High
INFLAMMATION 309 82.80 Quite High
Metaplasia 18 81.68 Quite High
Infection 15 77.60 Quite High
Alagille Syndrome 2 74.76 Quite High
Blister 2 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At interrupted Ag-challenge sites, histamine levels decreased abruptly, and tryptase levels decreased progressively after the first hour.
Negative_regulation (decreased) of tryptase
1) Confidence 0.58 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1695232 Disease Relevance 0.18 Pain Relevance 0.06
At continuous Ag-challenge sites, there was a plateau of histamine levels (8.0 to 9.5 ng/ml) during the next 4 hours, whereas tryptase levels decreased progressively to baseline levels.
Negative_regulation (decreased) of tryptase
2) Confidence 0.58 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1695232 Disease Relevance 0.22 Pain Relevance 0.08
The responder and poor responder groups did not differ significantly in mean age, pain duration, VAS for pain, or number of TPs.
Negative_regulation (number) of TPs associated with pain and visual analogue scale
3) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888218 Disease Relevance 0.59 Pain Relevance 0.64
In other small clinical trials, suplatast decreased blood and sputum eosinophils, blood and sputum eosinophil cationic protein levels, sputum mast cell tryptase levels, exhaled nitric oxide and airway responsiveness in patients with mild-moderate asthma or cough-variant asthma without causing significant side-effects [8].


Negative_regulation (decreased) of tryptase in sputum associated with asthma and cough
4) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.28 Pain Relevance 0.07
In other small clinical trials, suplatast decreased blood and sputum eosinophils, blood and sputum eosinophil cationic protein levels, sputum mast cell tryptase levels, exhaled nitric oxide and airway responsiveness in patients with mild-moderate asthma or cough-variant asthma without causing significant side-effects [8].


Negative_regulation (decreased) of tryptase in eosinophils associated with asthma and cough
5) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.28 Pain Relevance 0.07
In other small clinical trials, suplatast decreased blood and sputum eosinophils, blood and sputum eosinophil cationic protein levels, sputum mast cell tryptase levels, exhaled nitric oxide and airway responsiveness in patients with mild-moderate asthma or cough-variant asthma without causing significant side-effects [8].


Negative_regulation (decreased) of tryptase in blood associated with asthma and cough
6) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.28 Pain Relevance 0.07

General Comments

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