INT144800

Context Info Confidence 0.22 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.23

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1) lipid metabolic process (TRPV1)

TRPV1 (Homo sapiens) ATP8A2 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 3 91.08 burning pain 1 71.72

Disease Link Frequency Relevance Heat Pain 1 71.72 Nociception 1 67.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We present a model for the calcium-dependent regulation of TRPV1 via competitive interactions of ATP and calmodulin at the TRPV1-ARD-binding site and discuss its relationship to the C-terminal region previously implicated in interactions with PIP2 and calmodulin.

TRPV1 Binding (interactions) of ATP

1) Confidence 0.22 Published 2007 Journal Neuron Section Abstract Doc Link 17582331 Disease Relevance 0.14 Pain Relevance 0.23

General Comments

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