INT144907

Context Info Confidence 0.53 First Reported 2002 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.57 Pain Relevance 0.43

cytosol (RAC3) plasma membrane (RAC3) GTPase activity (RAC3) cytoplasm (RAC3)

Anatomy Link Frequency muscle 1 RAC3 (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 4 100.00 antagonist 3 100.00 tetrodotoxin 1 100.00 dorsal root ganglion 3 96.60 agonist 5 5.00 Potency 3 5.00 Inflammation 1 5.00 psoriasis 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Poisoning 1 99.60 Ganglion Cysts 3 96.60 Paralysis 2 81.64 Syndrome 1 53.28 Reprotox - General 1 1 49.52 Hypersensitivity 6 5.00 Repression 2 5.00 Toxicity 2 5.00 Adenocarcinoma 1 5.00 Wrinkles 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, the behavioral effects of crotamine intoxication were compared with those of a muscle-selective sodium channel antagonist mu-CgTx-GIIIA, and other sodium-acting toxins such as tetrodotoxin alpha- and beta-pompilidotoxins, sea anemone toxin BcIII, spider toxin Tx2-6.

Gene_expression (those) of anemone toxin BcIII in muscle associated with tetrodotoxin, antagonist, sodium channel and poisoning

1) Confidence 0.53 Published 2007 Journal Toxicon Section Abstract Doc Link 17588630 Disease Relevance 0.57 Pain Relevance 0.43

We then assayed similarly expression levels for nuclear coactivators AIB1 [16], CBP [17], p300 [18], p/CIP [19], RAC3 [20], RIP140 [21], SRC1 [22], TIF1 [23], TIF2 [24] and TRIP1 [25].

Gene_expression (expression) of RAC3

2) Confidence 0.21 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0

General Comments

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