INT144993

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 5.70
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Epor) extracellular region (Epor) plasma membrane (Epor)
embryo development (Epor)
Anatomy Link Frequency
neuronal 1
BFU-E 1
nervous system 1
GCT 1
Epor (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 10 99.68 Very High Very High Very High
cva 70 98.76 Very High Very High Very High
bDMF 8 95.84 Very High Very High Very High
medulla 350 92.00 High High
midbrain 10 70.16 Quite High
ischemia 2 55.20 Quite High
long-term potentiation 28 50.00 Quite Low
Multiple sclerosis 2 16.48 Low Low
Hippocampus 42 5.00 Very Low Very Low Very Low
depression 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 130 99.52 Very High Very High Very High
Cv General 3 Under Development 70 98.76 Very High Very High Very High
Cerebral Malaria 300 98.48 Very High Very High Very High
Neurological Disease 20 96.40 Very High Very High Very High
Hematological Disease 6 96.20 Very High Very High Very High
Malaria 660 95.20 Very High Very High Very High
Cognitive Disorder 54 94.96 High High
Anaemia 52 91.76 High High
Rupture 10 90.44 High High
Jaundice 20 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although no studies have directly shown a role for CD131 in binding Epo to the surface of any cell (reviewed in [41]), CD131 has been shown to physically and/or functionally associate with EpoR and coexpression of these receptors have been observed using immunohistochemistry in tissue sections from neurological disease models in animals [28,42,43].
Gene_expression (coexpression) of EpoR associated with neurological disease
1) Confidence 0.75 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.68 Pain Relevance 0
Concordant or discordant expression of Epo, EpoR and CD131 were assessed by performing immunolabelling on serial sections.
Gene_expression (expression) of EpoR
2) Confidence 0.75 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.11 Pain Relevance 0.03
Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Krüppel-like factor 1 (KLF1) in the BFU-E colonies.
Gene_expression (expression) of EpoR in BFU-E associated with qutenza
3) Confidence 0.72 Published 2007 Journal Exp. Mol. Med. Section Abstract Doc Link 17603282 Disease Relevance 0.16 Pain Relevance 0.74
Although CD131 showed staining of the same cell subsets as EpoR concordance was not always observed.
Gene_expression (concordance) of EpoR
4) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.44 Pain Relevance 0
Relationship between Epo, EpoR and CD131 immunostaining and vascular permeability and haemorrhage
Gene_expression (immunostaining) of EpoR associated with cva
5) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.43 Pain Relevance 0.19
Glial staining of EpoR and CD131 was heterogeneous across cases and discordant in incidence and location in serial sections with only 15% (3/20) of severe malaria cases showing a similar incidence of both markers and one case showing no staining for either marker.
Gene_expression (staining) of EpoR associated with malaria
6) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.46 Pain Relevance 0
Epo, EpoR and CD131 were visualized using exceptionally high sensitivity detection systems (Leica Microsystems, DAKO) that preclude the possibility of double labelling procedures on the same tissue sections.
Gene_expression (visualized) of EpoR
7) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.07 Pain Relevance 0.04
Relationship between Epo, EpoR and CD131 immunostaining and organ failure
Gene_expression (immunostaining) of EpoR
8) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.29 Pain Relevance 0.24
Relationship between Epo, EpoR, CD131 and neuroprotection

(i) Axonal injury, astrogliosis and neuronal chromatolysis

Gene_expression (neuroprotection) of EpoR in neuronal associated with injury
9) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.21 Pain Relevance 0.08
Relationship between Epo, EpoR and CD131 immunostaining, parasite load and cerebral sequestration
Gene_expression (immunostaining) of EpoR
10) Confidence 0.65 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.48 Pain Relevance 0.04
mouse EPOR fwd: CCT CAT CTC GTT GTT GCT GA
Gene_expression (fwd) of EPOR in GCT
11) Confidence 0.48 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0 Pain Relevance 0.19
However, the finding that EPO and its receptor (EPOR) are expressed in the brain [6,7] (for review see also [1,3,8-11]) led to the notion that EPO exerts direct, hematopoiesis-independent effects on the nervous system.
Gene_expression (expressed) of EPOR in nervous system associated with hematological disease
12) Confidence 0.43 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0.79 Pain Relevance 0.03
In line with the findings for EpoR, CD131 levels on glia were heterogeneous across all patient groups (Figure 2F).
Gene_expression (levels) of EpoR
13) Confidence 0.29 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.57 Pain Relevance 0.04

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