INT145077

Context Info Confidence 0.19 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Title Documents 2 Total Number 2 Disease Relevance 3.00 Pain Relevance 1.10

plasma membrane (SLC22A5) transmembrane transport (SLC22A5)

SLC22A5 (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 37 99.72 Gabapentin 12 98.88 anticonvulsant 1 97.72 Bile 2 73.76 Inflammation 13 72.64 Inflammatory mediators 1 69.92 Bioavailability 1 39.36 cytokine 1 5.00 spinal inflammation 1 5.00 psoriasis 1 5.00

Disease Link Frequency Relevance Heat Disease 57 99.72 Genetic Predisposition To Disease 3 99.60 Inflammatory Bowel Disease 21 96.84 Biliary Liver Cirrhosis 15 96.28 Epilepsy 1 95.92 Primary Sclerosing Cholangitis 21 95.84 Neuropathic Pain 1 95.16 Disease Susceptibility 3 92.40 Autoimmune Disease 2 91.00 Liver Disease 2 84.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been reported that the genetic predisposition to CD is caused by alterations in several genes, including NOD2/CARD15, OCTN1, OCTN2, DLG, ATG16L1 and IL23R [11-14].

Regulation (alterations) of OCTN2 associated with crohn's disease and genetic predisposition to disease

1) Confidence 0.19 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 2.81 Pain Relevance 0.35

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.

Regulation (Effects) of OCTN1 associated with gabapentin

2) Confidence 0.05 Published 2008 Journal Clin. Pharmacol. Ther. Section Title Doc Link 17609685 Disease Relevance 0.19 Pain Relevance 0.74

General Comments

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