INT145120

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0.72

signal transduction (Oprm1) nuclear chromosome (Msh3) plasma membrane (Oprm1) nucleus (Msh3) enzyme binding (Msh3) DNA binding (Msh3)

Anatomy Link Frequency neurons 2 Msh3 (Mus musculus) Oprm1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 5 100.00 gABA 7 99.00 Glutamate 2 98.34 antagonist 1 90.88 Action potential 1 83.48 agonist 2 68.56 GABAergic 1 63.88 Opioid 1 62.68

Disease Link Frequency Relevance Heat Infection 1 92.00 Targeted Disruption 1 57.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Glutamate photolysis stimulation of intact NTS projections evoked IPSCs in DMV neurons, and EM-1 reduced the evoked response, most likely by activation of MOR on the soma of premotor GABA neurons in NTS.

EM-1 Negative_regulation (reduced) of Positive_regulation (activation) of MOR in neurons associated with gaba, glutamate and opioid receptor

1) Confidence 0.05 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17615134 Disease Relevance 0.15 Pain Relevance 0.72

General Comments

This test has worked.