INT145155

Context Info Confidence 0.38 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.54 Pain Relevance 0.33

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR) endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)

Anatomy Link Frequency thyroid 6 EGFR (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 12 99.56 palliative 12 62.92 Glutamate 3 51.12 cINOD 34 5.00 Inflammation 6 5.00 Sicca syndrome 3 5.00 Pain 3 5.00 headache 3 5.00 antagonist 2 5.00 COX2 2 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 483 99.64 Apoptosis 48 99.44 Metastasis 49 98.64 Cancer 200 97.08 Multiple Endocrine Neoplasia 12 95.88 Hereditary Neoplastic Syndromes 3 95.28 Breast Cancer 61 88.48 Carcinoma 69 85.68 Chromosome Inversion 3 84.52 Lung Cancer 48 75.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The cells were then harvested at 48 h after treatment and analyzed by western blot and RT-PCR to evaluate the effect of the drugs on expression and mRNA levels of EGFR and COX-2.

Regulation (evaluate) of Positive_regulation (levels) of EGFR

1) Confidence 0.38 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.08 Pain Relevance 0

More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).

Regulation (regulated) of Positive_regulation (activation) of EGFR in thyroid associated with thyroid neoplasm and metalloproteinase

2) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.89 Pain Relevance 0.23

Some studies suggest that differentiated thyroid carcinoma cell invasion is regulated through epidermal growth factor receptor-dependent (EGFR) activation of matrix metalloproteinases (Yeh et al 2006).

Regulation (regulated) of Positive_regulation (activation) of EGFR in thyroid associated with thyroid neoplasm and metalloproteinase

3) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.40 Pain Relevance 0.05

Some studies suggest that differentiated thyroid carcinoma cell invasion is regulated through epidermal growth factor receptor-dependent (EGFR) activation of matrix metalloproteinases (Yeh et al 2006).

Regulation (regulated) of Positive_regulation (activation) of epidermal growth factor receptor-dependent in thyroid associated with thyroid neoplasm and metalloproteinase

4) Confidence 0.29 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.40 Pain Relevance 0.05

regulation of EGFR activation may decrease apoptosis, increase metastasis and

Regulation (regulation) of Positive_regulation (activation) of EGFR associated with apoptosis and metastasis

5) Confidence 0.27 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.52 Pain Relevance 0

The effect of sulindac sulfone on basal EGFR activation and expression was also examined.

Spec (examined) Regulation (effect) of Positive_regulation (activation) of EGFR

6) Confidence 0.27 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.25 Pain Relevance 0

Distinct effects on EGFR activation may specify the subset of AP-1 target genes that are selected, including those involved in proliferation and apoptosis.

Regulation (effects) of Positive_regulation (activation) of EGFR

7) Confidence 0.24 Published 2007 Journal Am. J. Gastroenterol. Section Body Doc Link 17617207 Disease Relevance 0 Pain Relevance 0

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