INT145155

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.54
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
thyroid 6
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 12 99.56 Very High Very High Very High
palliative 12 62.92 Quite High
Glutamate 3 51.12 Quite High
cINOD 34 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Sicca syndrome 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 483 99.64 Very High Very High Very High
Apoptosis 48 99.44 Very High Very High Very High
Metastasis 49 98.64 Very High Very High Very High
Cancer 200 97.08 Very High Very High Very High
Multiple Endocrine Neoplasia 12 95.88 Very High Very High Very High
Hereditary Neoplastic Syndromes 3 95.28 Very High Very High Very High
Breast Cancer 61 88.48 High High
Carcinoma 69 85.68 High High
Chromosome Inversion 3 84.52 Quite High
Lung Cancer 48 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells were then harvested at 48 h after treatment and analyzed by western blot and RT-PCR to evaluate the effect of the drugs on expression and mRNA levels of EGFR and COX-2.
Regulation (evaluate) of Positive_regulation (levels) of EGFR
1) Confidence 0.38 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.08 Pain Relevance 0
More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).
Regulation (regulated) of Positive_regulation (activation) of EGFR in thyroid associated with thyroid neoplasm and metalloproteinase
2) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.89 Pain Relevance 0.23
Some studies suggest that differentiated thyroid carcinoma cell invasion is regulated through epidermal growth factor receptor-dependent (EGFR) activation of matrix metalloproteinases (Yeh et al 2006).
Regulation (regulated) of Positive_regulation (activation) of EGFR in thyroid associated with thyroid neoplasm and metalloproteinase
3) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.40 Pain Relevance 0.05
Some studies suggest that differentiated thyroid carcinoma cell invasion is regulated through epidermal growth factor receptor-dependent (EGFR) activation of matrix metalloproteinases (Yeh et al 2006).
Regulation (regulated) of Positive_regulation (activation) of epidermal growth factor receptor-dependent in thyroid associated with thyroid neoplasm and metalloproteinase
4) Confidence 0.29 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.40 Pain Relevance 0.05
regulation of EGFR activation may decrease apoptosis, increase metastasis and
Regulation (regulation) of Positive_regulation (activation) of EGFR associated with apoptosis and metastasis
5) Confidence 0.27 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.52 Pain Relevance 0
The effect of sulindac sulfone on basal EGFR activation and expression was also examined.
Spec (examined) Regulation (effect) of Positive_regulation (activation) of EGFR
6) Confidence 0.27 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.25 Pain Relevance 0
Distinct effects on EGFR activation may specify the subset of AP-1 target genes that are selected, including those involved in proliferation and apoptosis.
Regulation (effects) of Positive_regulation (activation) of EGFR
7) Confidence 0.24 Published 2007 Journal Am. J. Gastroenterol. Section Body Doc Link 17617207 Disease Relevance 0 Pain Relevance 0

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