INT14516

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.60
Pain Relevance 6.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CRTAC1) proteinaceous extracellular matrix (CRTAC1)
Anatomy Link Frequency
astrocyte 2
spinal cord 1
striatum 1
brain 1
neuronal 1
CRTAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 3 100.00 Very High Very High Very High
Morphine 39 99.82 Very High Very High Very High
tetrodotoxin 2 99.06 Very High Very High Very High
cocaine 12 98.20 Very High Very High Very High
Ventral tegmentum 17 97.88 Very High Very High Very High
Neurotransmitter 4 97.16 Very High Very High Very High
Dorsal horn 1 96.64 Very High Very High Very High
Immobilon 8 96.24 Very High Very High Very High
conotoxin 2 95.24 Very High Very High Very High
mu opioid receptor 1 94.20 High High
Disease Link Frequency Relevance Heat
Colon Cancer 1 99.48 Very High Very High Very High
Cancer 41 98.58 Very High Very High Very High
Neurocytoma 5 96.88 Very High Very High Very High
Drug Induced Neurotoxicity 1 96.88 Very High Very High Very High
Sprains And Strains 3 92.56 High High
Cyst 4 90.60 High High
Oligodendroglioma 1 87.48 High High
Aging 103 83.88 Quite High
Recurrence 3 83.36 Quite High
Apoptosis 32 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histochemical and immunohistochemical studies showed that almost all were reactive to periodic acid schiff stain, epithelial membrane antigen, and carcino-embryonic antigen, but negative to glial fibrillary acidic protein.
Positive_regulation (negative) of acidic protein
1) Confidence 0.37 Published 2008 Journal Acta Neurochir (Wien) Section Abstract Doc Link 18213442 Disease Relevance 0.65 Pain Relevance 0.20
Stimulation of cut nerves prevented glial fibrillary acidic protein increases even when postsynaptic nicotinic receptors were blocked, but not when neurotransmitter release was blocked with omega-conotoxin GVIA.
Positive_regulation (increases) of acidic protein in nerves associated with neurotransmitter and conotoxin
2) Confidence 0.07 Published 1994 Journal Neuron Section Abstract Doc Link 7906531 Disease Relevance 0 Pain Relevance 0.23
When deprived of neuronal activity in vivo, either by motor nerve transection or tetrodotoxin injection, perisynaptic Schwann cells rapidly up-regulated glial fibrillary acidic protein.
Positive_regulation (up-regulated) of acidic protein in neuronal associated with tetrodotoxin
3) Confidence 0.05 Published 1994 Journal Neuron Section Abstract Doc Link 7906531 Disease Relevance 0 Pain Relevance 0.21
Immunohistochemical examination showed the tumor cells to be strongly positive for neuron-specific enolase, sparsely positive for S-100 protein, and negative for glial fibrillary acidic protein.
Positive_regulation (negative) of acidic protein in neuron associated with cancer
4) Confidence 0.02 Published 1990 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 1697045 Disease Relevance 1.07 Pain Relevance 0.07
Relative to drug-naive Fischer 344 rats, drug-naive Dark Agouti rats showed higher levels of tyrosine hydroxylase and glial fibrillary acidic protein, and lower levels of neurofilament proteins, in the ventral tegmental area.
Positive_regulation (levels) of acidic protein in ventral associated with ventral tegmentum
5) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336139 Disease Relevance 0.22 Pain Relevance 0.55
Incubation of astrocytes with idazoxan, but not rauwolscine, resulted in a concentration-dependent increase in the levels of mRNA for the astrocyte specific molecule glial fibrillary acidic protein.
Positive_regulation (increase) of acidic protein in astrocyte
6) Confidence 0.01 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8315666 Disease Relevance 0 Pain Relevance 0.22
Tumor cells were strongly reactive for vimentin and S-100 protein, variably positive for glial fibrillary acidic protein, and nonreactive for synaptophysin and neurofilament protein.
Positive_regulation (positive) of acidic protein associated with cancer
7) Confidence 0.01 Published 2000 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 10716149 Disease Relevance 1.08 Pain Relevance 0.07
Moreover, immune parameters specifically related to the age of colorectal cancer patients, such as higher levels of C3, C4 and immunosuppressive acidic protein (IAP), and lower T cell stimulation index could contribute to cancer development and explain why they respond to a lesser extent to adjuvant immunochemotherapy than immunologically intact young subjects (Munemoto et al 2004).
Positive_regulation (levels) of acidic protein in T cell associated with cancer and colon cancer
8) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.12 Pain Relevance 0.03
Importantly, meth self-administration was associated with significant dose-dependent increases in glial fibrillary acidic protein in both striatum and cortex, with these changes being of greater magnitude in the striatum.
Positive_regulation (increases) of acidic protein in striatum
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808335 Disease Relevance 0 Pain Relevance 0.24
Furthermore, we found that the level of glial fibrillary acidic protein in the mouse spinal cord was clearly increased by chronic in vivo and in vitro treatment with morphine, whereas no such effect was noted by etorphine.
Positive_regulation (increased) of acidic protein in spinal cord associated with immobilon, morphine and spinal cord
10) Confidence 0.00 Published 2006 Journal Neuroscience Section Abstract Doc Link 16417975 Disease Relevance 0 Pain Relevance 1.46
We found that treatment of mouse purified astrocytes and neurone/glia cocultures with BPA in vitro caused the activation of astrocytes, as detected by a stellate morphology and an increase in levels of glial fibrillary acidic protein.
Positive_regulation (increase) of acidic protein in astrocytes
11) Confidence 0.00 Published 2006 Journal J. Neuroendocrinol. Section Abstract Doc Link 16684133 Disease Relevance 0.16 Pain Relevance 0.25
Chronic morphine treatment also increases levels of glial fibrillary acidic protein in this brain region.
Positive_regulation (increases) of acidic protein in brain associated with morphine
12) Confidence 0.00 Published 1995 Journal Neuroscience Section Abstract Doc Link 8545003 Disease Relevance 0 Pain Relevance 0.69
In addition, neurotrophin-4 prevented the morphine-induced increase in glial fibrillary acidic protein.
Positive_regulation (increase) of acidic protein associated with morphine
13) Confidence 0.00 Published 1995 Journal Neuroscience Section Abstract Doc Link 8545003 Disease Relevance 0 Pain Relevance 1.36
No increases in the astrocytic marker glial fibrillary acidic protein were noted following treatment with SP-SAP, suggesting a lack of generalized neurotoxicity.
Neg (No) Positive_regulation (increases) of acidic protein associated with drug induced neurotoxicity
14) Confidence 0.00 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16500924 Disease Relevance 0.30 Pain Relevance 0.43

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