INT145195

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.65
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak3) nucleus (Irak3) kinase activity (Irak3)
cytoplasm (Irak3)
Anatomy Link Frequency
monocytes 3
macrophages 1
Irak3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 100.00 Very High Very High Very High
cytokine 19 100.00 Very High Very High Very High
tolerance 90 99.84 Very High Very High Very High
Inflammatory response 6 99.18 Very High Very High Very High
Angina 3 92.60 High High
agonist 6 48.52 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 100.00 Very High Very High Very High
Acute Coronary Syndrome 18 99.98 Very High Very High Very High
Myocardial Infarction 6 96.40 Very High Very High Very High
Heart Disease 3 95.80 Very High Very High Very High
Cv General 3 Under Development 3 92.60 High High
Infection 10 55.96 Quite High
Sepsis 20 52.40 Quite High
Disease 4 38.48 Quite Low
Necrosis 2 23.88 Low Low
Cancer 2 23.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammatory responses associated with acute coronary syndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytes.
Positive_regulation (up-regulate) of IRAK-M in monocytes associated with acute coronary syndrome, inflammatory response and tolerance
1) Confidence 0.15 Published 2007 Journal J. Endotoxin Res. Section Title Doc Link 17621545 Disease Relevance 1.15 Pain Relevance 0.46
Control monocytes cultured for 6 h in supplemented medium (10% serum from ACS patients) expressed IRAK-M, and LPS stimulation failed to induce TNF-alpha and IL-6 in these cultures.
Neg (failed) Positive_regulation (failed) of IRAK-M in monocytes associated with acute coronary syndrome
2) Confidence 0.15 Published 2007 Journal J. Endotoxin Res. Section Abstract Doc Link 17621545 Disease Relevance 1.10 Pain Relevance 0.46
Circulating monocytes from all patients, but not from healthy individuals, showed high levels of pro-inflammatory cytokines, TNF-alpha and IL-6, as well as of IRAK-M and IL-10.
Positive_regulation (levels) of IRAK-M in monocytes associated with inflammation and cytokine
3) Confidence 0.14 Published 2007 Journal J. Endotoxin Res. Section Abstract Doc Link 17621545 Disease Relevance 1.11 Pain Relevance 0.47
Contrary to the upregulation of IRAK-M, the critical signaling kinase, IRAK-1, is downregulated at the levels of protein and RNA in endotoxin-tolerant macrophages (17, 18).
Positive_regulation (upregulation) of IRAK-M in macrophages
4) Confidence 0.07 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.12 Pain Relevance 0.37
Another critical mechanism by which signal transduction is inhibited in tolerance is the upregulation of negative regulators of signaling, e.g., IRAK-M.
Positive_regulation (upregulation) of IRAK-M associated with tolerance
5) Confidence 0.07 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.17 Pain Relevance 0.36

General Comments

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