INT145253

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.02
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
plasma 1
tube 1
vessels 1
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 8 80.24 Quite High
isoflurane 6 79.80 Quite High
Inflammatory mediators 8 56.24 Quite High
Kinase C 1 45.76 Quite Low
cytokine 8 40.76 Quite Low
Neurotransmitter 16 28.84 Quite Low
Glutamate 10 18.72 Low Low
addiction 6 9.44 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
Dopamine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 100.00 Very High Very High Very High
Syndrome 12 97.24 Very High Very High Very High
Stress 62 91.96 High High
Cancer 72 89.68 High High
Channelopathies 34 88.00 High High
Cv Unclassified Under Development 1 83.20 Quite High
Experimental Melanoma 1 80.72 Quite High
Colon Cancer 33 78.20 Quite High
Hearing Impairment 2 74.72 Quite High
Solid Tumor 1 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, based on data from homozygous Cav1.3 knockout mice, it is very likely that complete loss of Cav1.3 function would not be lethal.
Negative_regulation (loss) of Cav1 associated with targeted disruption
1) Confidence 0.46 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.92 Pain Relevance 0
The decrease in current density when cells are depleted of cav-1 could reflect a role for cav-1 in trafficking of the maxi-K channel to the plasma membrane.
Negative_regulation (depleted) of cav-1 in plasma
2) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
We conclude that NO affects blood pressure more in Cav-1 KO than in WT mice and that restructuring of resistance vessels and an increased responsiveness to adrenergic stimulation compensate for a decreased tone in Cav-1 KO mice.
Negative_regulation (decreased) of Cav-1 KO in vessels associated with targeted disruption
3) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17626133 Disease Relevance 0.81 Pain Relevance 0.12
In Cav1.2, VDI is also inhibited by mutation of nearby residues such as a serine residue important for slow inactivation in IS6 and G406 in Timothy syndrome (G406R) [72].
Negative_regulation (inhibited) of Cav1 associated with syndrome
4) Confidence 0.34 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.28 Pain Relevance 0
Inhibiting the cav-1 gene in hMSMCs demonstrated the significance of the maxi-K-caveolin interactions for the excitability of myometrial cells.
Negative_regulation (Inhibiting) of cav-1 gene
5) Confidence 0.33 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.09 Pain Relevance 0
Interestingly, all three of the mutants used in this study reproduced the inhibitory effects of cav-1 deficiency on maxi-K channel current in hMSMCs, although only in the case of mutant Y1007A, F1012A, Y1015A was the maxi-K-caveolin complex disrupted.
Negative_regulation (deficiency) of cav-1
6) Confidence 0.33 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.06 Pain Relevance 0
Our results showing that inhibiting the cav-1 gene in hMSMCs leads to decreased maxi-K channel current demonstrate the significance of the maxi-K-caveolin interactions for the excitability of myometrial cells.
Negative_regulation (inhibiting) of cav-1 gene
7) Confidence 0.33 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
Ltk- cells expressing wild-type and mutant channels (see Transfections), and hMSMC in which the caveolin-1 gene was inhibited (see siRNA) were placed in a pH 7.4 bath solution containing, in mM: 135 NaCl, 4.7 KCl, 1 MgCl2, 10 Glucose, 2 CaCl2 and 5 Hepes.
Negative_regulation (inhibited) of caveolin-1
8) Confidence 0.33 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
For example, overexpression of caveolin-1 significantly enhances endothelial cell differentiation into tube-like structures and downregulation of caveolin-1 protein levels using antisense oligonucleotides reduced the ability of the endothelial cells to form an organized network (Liu et al. 2002; Griffoni et al. 2000).
Negative_regulation (downregulation) of caveolin-1 in tube
9) Confidence 0.19 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.76 Pain Relevance 0
Downregulation of Cav-1 leads to activation of these signaling pathways.
Negative_regulation (Downregulation) of Cav-1
10) Confidence 0.13 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.11 Pain Relevance 0.03

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