INT145268

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.62
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC5) ATPase activity (ABCC5) plasma membrane (ABCC5)
transmembrane transport (ABCC5)
Anatomy Link Frequency
livers 1
ABCC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.12 Very High Very High Very High
Bile 2 61.04 Quite High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 16 99.92 Very High Very High Very High
Disease 2 99.64 Very High Very High Very High
Overdose 6 99.48 Very High Very High Very High
Breast Cancer 2 81.68 Quite High
Acute Liver Failure 2 75.00 Quite High
Liver Failure 2 69.52 Quite High
Injury 4 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Positive_regulation (increased) of MRP5 associated with biliary liver cirrhosis and disease
1) Confidence 0.58 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.36 Pain Relevance 0.57
Up-regulation of MRP5, MDR1, and BCRP mRNA occurred in PBC livers.
Positive_regulation (Up-regulation) of MRP5 in livers associated with biliary liver cirrhosis
2) Confidence 0.58 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.27 Pain Relevance 0.56

General Comments

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