INT145362

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RORA) signal transduction (RORA) nucleus (RORA)
Anatomy Link Frequency
T cells 2
RORA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 90.00 High High
Inflammation 43 78.48 Quite High
Inflammatory mediators 2 67.04 Quite High
rheumatoid arthritis 1 50.00 Quite Low
cINOD 1 25.20 Quite Low
agonist 4 25.00 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 3 87.84 High High
Disease 18 82.64 Quite High
INFLAMMATION 50 78.48 Quite High
Cancer 2 57.36 Quite High
Infection 4 52.80 Quite High
Rheumatoid Arthritis 61 50.00 Quite Low
Pneumonia 1 38.88 Quite Low
Stress 1 28.24 Quite Low
Immunotherapy Of Cancer 1 25.00 Low Low
Granuloma 2 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH(2)-terminal kinase) or the Ca(2+)-dependent (NLK and nuclear factor of activated T cells) signaling cascades.
Positive_regulation (transduced) of ROR2 in T cells
1) Confidence 0.49 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17634527 Disease Relevance 0.06 Pain Relevance 0
, naïve T cells develop into Th17 cells through activation of STAT3 and induction of the transcription factor retinoic acid-related orphan receptor (RORgammat).
Positive_regulation (induction) of transcription factor retinoic acid-related orphan receptor in T cells
2) Confidence 0.06 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.47 Pain Relevance 0.14
Among cholesterol derivatives capable of activating ROR-?
Positive_regulation (activating) of ROR
3) Confidence 0.01 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.08 Pain Relevance 0

General Comments

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