INT145375

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.86
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
embryos 1
T-cell 1
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 1 93.88 High High
Kinase C 3 50.72 Quite High
Central nervous system 1 47.20 Quite Low
antagonist 12 42.24 Quite Low
cINOD 20 25.00 Low Low
agonist 19 25.00 Low Low
Nicotine 5 21.36 Low Low
depression 1 6.08 Low Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
Inflammation 37 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 2 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 44 98.36 Very High Very High Very High
Adhesions 14 97.60 Very High Very High Very High
Breast Cancer 58 96.00 Very High Very High Very High
Apoptosis 189 95.44 Very High Very High Very High
Lung Cancer 68 94.48 High High
Cancer 274 92.08 High High
Fever 42 88.68 High High
Hyperplasia 3 86.24 High High
Death 35 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear complex, consisting of T-cell factor/lymphoid enhancer factor, beta-catenin, BCL9/BCL9L, and PYGO, activates transcription of canonical WNT target genes such as FGF20, DKK1, WISP1, MYC, CCND1, and Glucagon (GCG).
Transcription (transcription) of CCND1 in T-cell
1) Confidence 0.52 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17634527 Disease Relevance 0 Pain Relevance 0
In contrast, the transcription of many other genes, such as cyclin D1, transglutaminase 1, carcinoembryonic antigen-related cell adhesion molecule 6, purinergic receptor P2X, ligand gated ion channel, 3, and ?
Transcription (transcription) of cyclin D1 associated with adhesions
2) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.10 Pain Relevance 0
Examples of ERE-induced genes include PR, c-fos, bcl-2 and cathepsin D, whereas pS2 and cyclin D1 are transcribed via the activator protein-1 response element.
Transcription (transcribed) of cyclin D1
3) Confidence 0.26 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.27 Pain Relevance 0.05
reduction in cyclin D1 mRNA expression [40].
Transcription (expression) of cyclin D1
4) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.95 Pain Relevance 0
Vallböhmer and colleagues (Vallbohmer et al 2005b) evaluated whether mRNA expression of EGFR and 4 other genes involved in EGFR signaling (cyclin D1, cyclooxygenase-2, VEGF, and IL-8) were associated with clinical outcome to single-agent cetuximab in a cohort of 39 patients with mCRC refractory to irinotecan and oxaliplatin.
Spec (whether) Transcription (expression) of cyclin D1
5) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.37 Pain Relevance 0
This study has demonstrated that the activation of Src leads to an activating phosphorylation of STAT3, a transcription factor known to regulate cyclin D1 transcription, an important positive regulator of cell proliferation.
Transcription (transcription) of cyclin D1
6) Confidence 0.14 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.97 Pain Relevance 0
with a reduction in cyclin D1 mRNA expression [84].
Transcription (expression) of cyclin D1
7) Confidence 0.08 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.97 Pain Relevance 0
In these embryos, the mRNA expression of v-jun sarcoma virus 17 oncogene homolog, FOS, 3-phosphoinositide dependent protein kinase-1 and Cyclin D1 was found to be downregulated by roughly twofold [54].
Transcription (expression) of Cyclin D1 in embryos associated with sarcoma
8) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

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