INT145856

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.64
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GZMB) peptidase activity (GZMB) nucleus (GZMB)
cytoplasm (GZMB)
Anatomy Link Frequency
T cells 2
lymphocyte 1
NK cells 1
GZMB (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 93.16 High High
cytokine 9 60.44 Quite High
Shingles 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Dermatone 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 86 98.00 Very High Very High Very High
Leukemia 2 98.00 Very High Very High Very High
Herpes Zoster 204 97.80 Very High Very High Very High
Myelofibrosis 1 97.12 Very High Very High Very High
Cancer 115 96.84 Very High Very High Very High
Pancytopenia 1 94.32 High High
Pain 1 93.16 High High
Recurrence 28 87.88 High High
Viremia 28 70.00 Quite High
Exanthema 36 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A slight increase in granzyme B-positive, CD56+ NK cells was detectable in the metastatic tissue which was taken after the cell-based therapy, whereas perforin was absent (Table 4).
Positive_regulation (increase) of granzyme B in NK cells
1) Confidence 0.10 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.55 Pain Relevance 0
Flow cytometric and histological analyses revealed that these cells were positive for CD3, TCRalphabeta, granzyme B, and the diagnosis of T-cell granular lymphocyte leukemia (T-GLL) with myelofibrosis was made.
Positive_regulation (positive) of granzyme B in lymphocyte associated with leukemia and myelofibrosis
2) Confidence 0.03 Published 2007 Journal Rinsho Ketsueki Section Abstract Doc Link 17695308 Disease Relevance 0.46 Pain Relevance 0.09
A considerable increase in granzyme B+ EM CD8 and CD4 T cells in both BAL (Figure 7B and C) and PBMCs (Figure 7D and E) was found in all samples as compared to levels at 0 dpi (Figure 7A, middle).
Positive_regulation (increase) of granzyme B in T cells
3) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.86 Pain Relevance 0.03
Since VZV infection is associated with the development of cytolytic CD4 and CD8 T cells [37],[38],[39], we measured an increase in granzyme B, a major component of cytolytic granules and an indicator of cytolytic activity.
Positive_regulation (increase) of granzyme B in T cells associated with herpes zoster and infection
4) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.78 Pain Relevance 0.03

General Comments

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