INT14596

Context Info Confidence 0.73 First Reported 1990 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 11 Disease Relevance 4.41 Pain Relevance 2.12

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency plasma 2 mast cells 2 spinal 1 neurons 1 skin 1 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 5 99.68 Inflammation 126 99.16 corticosteroid 9 99.04 cytokine 20 98.96 Spinal cord 5 98.92 Codeine 10 97.90 agonist 7 94.84 Hyperalgesia 2 91.96 allodynia 2 91.28 antagonist 6 85.32

Disease Link Frequency Relevance Heat INFLAMMATION 134 99.16 Hypersensitivity 10 97.16 Increased Venous Pressure Under Development 3 95.44 Nociception 3 95.16 Hyperalgesia 2 91.96 Neuropathic Pain 7 91.28 Disease 14 90.48 Renal Failure 4 89.12 Coronary Artery Disease 4 87.68 Targeted Disruption 27 70.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The localization of the PGD2 receptors DP1 and CRTH in spinal cord neurons, particularly in neurons of lamina I and II involved in the processing of nociceptive stimuli, supports a role of PGD2 under inflammatory conditions.

Localization (localization) of PGD2 in neurons associated with nociception, inflammation and spinal cord

1) Confidence 0.73 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.39 Pain Relevance 0.28

Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors.

Localization (localization) of PGD2 in spinal associated with cytokine

2) Confidence 0.68 Published 2008 Journal J. Neurochem. Section Title Doc Link 18028337 Disease Relevance 0.34 Pain Relevance 0.45

Importantly, we could demonstrate that PGD2 was operating directly on the neutrophils, because when these cells were harvested after migrating across a TNF-stimulated endothelial cells they had up-regulated CD11b (the alpha subunit of the ?

Localization (operating) of PGD2 in neutrophils

3) Confidence 0.67 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.09

The normalization of the PGD2:PGE2 ratio by the root extracts paralleled the inhibition of TNF-?

Localization (normalization) of PGD2

4) Confidence 0.61 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.68 Pain Relevance 0.28

There are two distinct types of PGDS: one is lipocalin-type PGDS (L-PGDS) localized in the central nervous system, male genitals, and heart; and the other is hematopoietic PGDS (H-PGDS) in mast cells and Th2 lymphocytes.

Localization (localized) of PGDS in mast cells associated with central nervous system

5) Confidence 0.61 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14695453 Disease Relevance 0.41 Pain Relevance 0.05

There are two distinct types of PGDS: one is lipocalin-type PGDS (L-PGDS) localized in the central nervous system, male genitals, and heart; and the other is hematopoietic PGDS (H-PGDS) in mast cells and Th2 lymphocytes.

Localization (localized) of L-PGDS in mast cells associated with central nervous system

6) Confidence 0.61 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14695453 Disease Relevance 0.41 Pain Relevance 0.05

L-PGDS is the same as beta-trace, a major protein in human cerebrospinal fluid, and is also secreted into the seminal plasma and plasma.

Localization (secreted) of L-PGDS in plasma

7) Confidence 0.61 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14695453 Disease Relevance 0.79 Pain Relevance 0.11

HM74a leads to a massive release of prostaglandin PGD2 and PGE2 [45–47].

Localization (release) of PGD2

8) Confidence 0.23 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.60 Pain Relevance 0.18

L-PGDS is the same as beta-trace, a major protein in human cerebrospinal fluid, and is also secreted into the seminal plasma and plasma.

Localization (secreted) of L-PGDS in plasma

9) Confidence 0.21 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14695453 Disease Relevance 0.79 Pain Relevance 0.11

In vivo antigen-induced cutaneous mediator release: simultaneous comparisons of histamine, tryptase, and prostaglandin D2 release and the effect of oral corticosteroid administration.

Localization (release) of prostaglandin D2 associated with corticosteroid and codeine

10) Confidence 0.02 Published 1990 Journal J. Allergy Clin. Immunol. Section Title Doc Link 1698845 Disease Relevance 0 Pain Relevance 0.39

To determine if basophils were responsible for the persistent release of histamine during continuous antigen (Ag) administration in the skin, we compared the release of histamine, tryptase, and prostaglandin D2 (PGD2) at sites of continuous (5 hours) and intermittent Ag and codeine skin-chamber challenge in the skin of 16 atopic and four nonatopic subjects.

Localization (release) of prostaglandin D2 in skin associated with codeine

11) Confidence 0.02 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1698845 Disease Relevance 0 Pain Relevance 0.13

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