INT145993

Context Info Confidence 0.67 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 4.40 Pain Relevance 1.16

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap) protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)

Anatomy Link Frequency photoreceptors 1 Xiap (Rattus norvegicus)

Pain Link Frequency Relevance Heat Sciatic nerve 9 96.64 Eae 3 91.36 Gabapentin 2 84.88 peripheral neuropathy 4 75.00 Hyperalgesia 2 63.92 allodynia 2 63.24 chronic pain syndrome 2 62.16 Pain 1 42.64 anesthesia 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 102 100.00 Targeted Disruption 9 94.00 Retinal Degeneration 12 89.96 Disease 13 80.76 Neuropathic Pain 7 75.00 Peripheral Neuropathy 6 75.00 Hyperalgesia 2 63.92 Retinal Diseases 3 62.96 Complex Regional Pain Syndromes 2 62.16 Muscle Weakness 2 59.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This protection correlates with the induction of X-linked inhibitor apoptosis protein (XIAP).

Positive_regulation (induction) of XIAP associated with apoptosis

1) Confidence 0.67 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17714181 Disease Relevance 1.31 Pain Relevance 0.51

This protection correlates with the induction of X-linked inhibitor apoptosis protein (XIAP).

Positive_regulation (induction) of X-linked inhibitor apoptosis protein associated with apoptosis

2) Confidence 0.60 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17714181 Disease Relevance 1.31 Pain Relevance 0.51

In our experience, increasing levels of XIAP have not had any deleterious effects on photoreceptors.

Positive_regulation (increasing) of XIAP in photoreceptors associated with apoptosis

3) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819556 Disease Relevance 1.30 Pain Relevance 0

This protection correlates with the induction of XIAP.

Positive_regulation (induction) of XIAP

4) Confidence 0.42 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19170187 Disease Relevance 0.49 Pain Relevance 0.13

General Comments

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