INT1463

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2010
Negated 8
Speculated 8
Reported most in Abstract
Documents 129
Total Number 136
Disease Relevance 15.89
Pain Relevance 56.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
brain 22
immune cells 4
pituitary 4
melanocyte 3
rectum 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 164 100.00 Very High Very High Very High
Enkephalin 144 100.00 Very High Very High Very High
narcan 135 100.00 Very High Very High Very High
Inflammation 83 100.00 Very High Very High Very High
opiate 81 100.00 Very High Very High Very High
Dynorphin 68 100.00 Very High Very High Very High
Morphine 61 100.00 Very High Very High Very High
Pain 41 100.00 Very High Very High Very High
Dopamine 39 100.00 Very High Very High Very High
Endogenous opioid 33 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 80 100.00 Very High Very High Very High
Pain 35 100.00 Very High Very High Very High
Hypothermia 7 99.96 Very High Very High Very High
Hypotension 15 99.74 Very High Very High Very High
Urological Neuroanatomy 38 99.68 Very High Very High Very High
Immunization 2 99.52 Very High Very High Very High
Injury 12 99.32 Very High Very High Very High
Aging 7 99.20 Very High Very High Very High
Burns 11 98.98 Very High Very High Very High
Convulsion 14 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that beta-endorphin 1-27 bindings with reduced affinity to the same receptors as beta-endorphin 1-31 and like the 31 residue peptide exhibits properties characteristic of an agonist.
beta-endorphin Binding (bindings) of associated with agonist
1) Confidence 0.48 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3020464 Disease Relevance 0 Pain Relevance 0.17
Observations suggest that the chronic presence of beta-endorphin, a biologically active opiate peptide, will interact with cells of the immune system, which have the ability to gain access to the cerebrospinal fluid.
beta-endorphin Binding (interact) of in immune system associated with opiate
2) Confidence 0.48 Published 1984 Journal Anat. Rec. Section Abstract Doc Link 6091499 Disease Relevance 0.09 Pain Relevance 0.62
In the present study the effects of intracerebroventricular (i.c.v.) administration of naloxone (10-20 ng), alone or in association with melatonin and/or beta-endorphin, on [3H]flunitrazepam ([3H]FNZ) binding to the rat cerebral cortex of hypophysectomized rats was investigated.
beta-endorphin Binding (association) of in cerebral cortex associated with narcan, cerebral cortex and intracerebroventricular
3) Confidence 0.48 Published 1993 Journal Neuroreport Section Abstract Doc Link 8396464 Disease Relevance 0 Pain Relevance 0.42
In their action on both thermoregulation and activity, naloxone and beta-endorphin appeared to interact independently with d-amphetamine, often producing effects in the same direction, but in combination, they tended to be mutually inhibitory.
beta-endorphin Neg (independently) Spec (appeared) Binding (interact) of associated with narcan
4) Confidence 0.48 Published 1980 Journal Peptides Section Abstract Doc Link 7243618 Disease Relevance 0.20 Pain Relevance 0.41
Results show a specific binding of 125I-beta-endorphin to chondrocytes, suggesting the possible existence of an opiate modulation of articular cartilage.
125I-beta-endorphin Binding (binding) of in chondrocytes associated with opiate
5) Confidence 0.48 Published 1991 Journal Life Sci. Section Abstract Doc Link 1654487 Disease Relevance 0 Pain Relevance 0.10
Use of antisera specifically recognizing the C-terminus of beta-, alpha-, and gamma-endorphin, respectively, revealed that only the beta-endorphin antiserum inhibited the fall in blood pressure in spontaneously hypertensive rats after cumulative administration of clonidine.
gamma-endorphin Binding (recognizing) of in blood associated with hypertension, hypotension and clonidine
6) Confidence 0.48 Published 1989 Journal Hypertension Section Abstract Doc Link 2536002 Disease Relevance 1.37 Pain Relevance 1.26
The reinforcing effect of beta-endorphin is most probably mediated by the mu and/or delta opioid subtype receptor, since beta-endorphin has a high affinity for these receptors.
beta-endorphin Binding (affinity) of associated with opioid
7) Confidence 0.48 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2950541 Disease Relevance 0.16 Pain Relevance 0.32
Fractions were assayed for their abilities to displace D-ala2-D-leu5-[tyrosyl, 3,53H] enkephalin from binding to rat brain membranes and 125I-beta-endorphin from binding to its antibody, and to stimulate corticosterone production by isolated rat adrenal cells.
125I-beta-endorphin Binding (binding) of in brain associated with enkephalin
8) Confidence 0.46 Published 1990 Journal Biochem. Int. Section Abstract Doc Link 2164396 Disease Relevance 0 Pain Relevance 0.26
CONCLUSION(S): Dydrogesterone interacts with allopregnanolone levels (less with beta-endorphin), and it can be considered important modulator of the neuroendocrine function.


beta-endorphin Binding (interacts) of
9) Confidence 0.46 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17531991 Disease Relevance 0 Pain Relevance 0
Thus, in our studies it appears that when tissue is inflamed and infiltrated by leukocytes, these cells might be a major target for POMC-MIDGE-NLS.
POMC-MIDGE-NLS Spec (might) Binding (target) of in leukocytes
10) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.30 Pain Relevance 0.31
Brain cholecystokinin and beta-endorphin systems may antagonistically interact to regulate tissue DNA synthesis in rat pups.
beta-endorphin Binding (interact) of in Brain associated with cholecystokinin
11) Confidence 0.43 Published 1994 Journal Brain Res. Section Title Doc Link 7834370 Disease Relevance 0 Pain Relevance 0.27
The binding of SP-40,40 to beta-endorphin inhibited the binding of beta-endorphin to its receptor of rat brain; thus SP-40,40 might inhibit the biological action of beta-endorphin.
beta-endorphin Binding (binding) of in brain
12) Confidence 0.42 Published 1993 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7689889 Disease Relevance 0 Pain Relevance 0.08
Beta h-Endorphin and nonradioactive iodo-Tyr27 beta h-endorphin were found to be identical in their ability to inhibit the binding of 125I-Tyr27 beta h-endorphin.
beta h-endorphin Binding (binding) of
13) Confidence 0.42 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3020464 Disease Relevance 0 Pain Relevance 0.18
In the present study, we examined the interaction between arcuate nucleus dopaminergic cells and accumbal beta-endorphin, during cocaine exposure.
beta-endorphin Spec (examined) Binding (interaction) of in arcuate nucleus associated with cocaine
14) Confidence 0.42 Published 2006 Journal Neuroreport Section Abstract Doc Link 17001283 Disease Relevance 0 Pain Relevance 0.57
Interactions of cholecystokinin, beta-endorphin, and their antagonists on passive avoidance behavior in rats.
beta-endorphin Binding (Interactions) of associated with antagonist, narcan and cholecystokinin
15) Confidence 0.42 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 2966663 Disease Relevance 0.57 Pain Relevance 0.53
Compared to 3H-dihydromorphine and 3H-D-ala2-D-leu5-enkephalin binding, 3H-beta-endorphin binding was far less sensitive to the reagent N-ethylmaleimide and more sensitive to the proteolytic enzyme trypsin.
beta-endorphin Binding (binding) of associated with enkephalin
16) Confidence 0.41 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292632 Disease Relevance 0 Pain Relevance 0.48
The regional distribution for 3H-beta-endorphin binding was also distinct from other 3H-ligands tested.
beta-endorphin Binding (binding) of
17) Confidence 0.41 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292632 Disease Relevance 0 Pain Relevance 0.47
Binding of 3H-beta-endorphin in rat brain.
beta-endorphin Binding (Binding) of in brain
18) Confidence 0.41 Published 1982 Journal Life Sci. Section Title Doc Link 6292632 Disease Relevance 0 Pain Relevance 0.40
Evidence that beta-endorphin binds to specific receptors in rat peripheral tissues and stimulates the adenylate cyclase-adenosine 3',5'-monophosphate system.
beta-endorphin Binding (binds) of associated with adenocard
19) Confidence 0.39 Published 1985 Journal Endocrinology Section Title Doc Link 2992912 Disease Relevance 0 Pain Relevance 0.05
To establish the materials responsible for binding opiates, the purified materials were cross-linked with 125I-labeled beta-endorphin using bis[2-(succinimidooxycarbonyloxy)-ethyl]sulfone as a cross-linker.
beta-endorphin Binding (cross-linked) of associated with opiate
20) Confidence 0.39 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2159852 Disease Relevance 0 Pain Relevance 0.49

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