INT146415

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
skeletal muscle 1
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 90.28 High High
Nerve growth factor 1 60.80 Quite High
substance P 22 53.04 Quite High
imagery 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
interstitial cystitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 15 95.60 Very High Very High Very High
Toxicity 2 95.20 Very High Very High Very High
Targeted Disruption 17 94.28 High High
Muscular Dystrophy 1 93.28 High High
INFLAMMATION 35 90.28 High High
Disease 16 81.68 Quite High
Sprains And Strains 2 80.32 Quite High
Shock 2 71.92 Quite High
Apoptosis 4 57.52 Quite High
Hypopituitarism 11 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted deletion of Smyd2 in cardiac tissue was accomplished by crossing mice expressing Cre recombinase under the control of the Nkx-2.5 promoter as described previously [41] into Smyd2 homozygous floxed mice and backcrossing the resulting heterozygous mice governing the Cre recombinase back to homozygous Smyd2flox/flox mice.
Regulation (control) of Nkx-2.5
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.17 Pain Relevance 0
It remains to be determined whether the control of Nkx-2.5 activity by gene silencing or double mutant negative blockers will ameliorate the clinical manifestations of cystitis.


Spec (whether) Regulation (control) of Nkx-2.5 associated with cystitis
2) Confidence 0.11 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.32 Pain Relevance 0.13
RESULTS AND CONCLUSION: The study showed 7-fold higher transcriptional activity of B1R in CSX vs. control and 3.5 higher vs.
Regulation (control) of CSX
3) Confidence 0.05 Published 2007 Journal Scand. Cardiovasc. J. Section Body Doc Link 17852785 Disease Relevance 0 Pain Relevance 0
Moreover, overexpression of DMPK 3' UTR mRNA in mouse skeletal muscle also induced transcriptional activation of Nkx2-5 and its targets.
Regulation (targets) of Nkx2-5 in skeletal muscle
4) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.42 Pain Relevance 0

General Comments

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