INT146521

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.29
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 99.38 Very High Very High Very High
palliative 1 84.72 Quite High
Potency 5 77.00 Quite High
induced neuropathy 3 69.04 Quite High
Chemotherapy induced neuropathy 1 65.40 Quite High
local anesthetic 1 51.92 Quite High
Nerve growth factor 7 42.96 Quite Low
sodium channel 1 37.92 Quite Low
Inflammation 34 21.80 Low Low
Inflammatory mediators 7 15.20 Low Low
Disease Link Frequency Relevance Heat
Cyst 21 99.00 Very High Very High Very High
Cancer 72 95.96 Very High Very High Very High
Carcinoid 6 95.68 Very High Very High Very High
Apoptosis 110 94.88 High High
Repression 2 93.28 High High
Neuroendocrine Cancer 1 89.52 High High
Hyperoxia 1 89.20 High High
Disease 44 83.44 Quite High
Stress 30 82.56 Quite High
Metastasis 4 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also shows anti-angiogenic properties [16] and anti-proliferative properties by inducing G1 arrest by loss of cyclin dependent kinase 2 activity and induction of p21 Waf1/Cip1 [19].
Negative_regulation (loss) of Positive_regulation (induction) of Cip1
1) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.82 Pain Relevance 0.17
Roscovitine decreases cell proliferation in parallel with p21 augmentation
Negative_regulation (decreases) of Positive_regulation (augmentation) of p21
2) Confidence 0.41 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.18 Pain Relevance 0
Western blot analysis showed a decrease in cyclin D1 and an increase in p21 and p27, indicating that the mechanism of this growth inhibition is cell cycle arrest.
Negative_regulation (decrease) of Positive_regulation (increase) of p21
3) Confidence 0.26 Published 2007 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17874277 Disease Relevance 1.15 Pain Relevance 0.08
Although a modest but significant increment on p15 and p21 mRNA expression was detected, this was not associated with clinical response.
Negative_regulation (detected) of Positive_regulation (increment) of p21
4) Confidence 0.14 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.31 Pain Relevance 0
Increased expression of p21 was not observed 24 h after exposure to cocaine in our study; however, we did detect an increase of p21 48 h after exposure to cocaine (unpublished data).
Negative_regulation (detect) of Positive_regulation (increase) of p21 associated with cocaine
5) Confidence 0.05 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.32 Pain Relevance 0.54
Complementing the PTEN regulation of AKT1 was a decrease in transcript for CDK2 combined with transcript increases for the CDK inhibitors p21 and GSK3?.
Negative_regulation (decrease) of Positive_regulation (increases) of p21
6) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.53 Pain Relevance 0

General Comments

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