INT146567

Context Info Confidence 0.43 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.72 Pain Relevance 0.83

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2) cytoplasm (Ccl2)

Anatomy Link Frequency DRG 2 Ccl2 (Mus musculus)

Pain Link Frequency Relevance Heat dorsal root ganglion 4 98.00 chemokine 1 97.40 Hyperalgesia 3 87.44 Gabapentin 1 82.56 Cancer pain 2 75.00 qutenza 1 71.88 nociceptor 2 62.08 Pain 2 25.00

Disease Link Frequency Relevance Heat Cancer 10 99.86 Ganglion Cysts 4 98.00 Fibrosarcoma 4 92.84 Hyperalgesia 3 87.44 Cancer Pain 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The CC chemokine ligand 2 (CCL2) may contribute to the tumor cell-induced sensitization because CCL2 immunoreactivity was present in tumors, high levels of CCL2 peptide were present in microperfusates from tumors, and treatment of DRG neurons in vitro with CCL2 increased the amount of mRNA for the alpha2delta1 subunit.

Negative_regulation (present) of Negative_regulation (levels) of CCL2 in DRG associated with dorsal root ganglion, chemokine and cancer

1) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17881535 Disease Relevance 1.72 Pain Relevance 0.83

General Comments

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