INT146941

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Latest revision as of 20:43, 24 September 2012

Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.36
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
C8-B4 4
spinal cord 2
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 70 99.78 Very High Very High Very High
IPN 1 98.44 Very High Very High Very High
Spinal cord 4 98.28 Very High Very High Very High
Brush evoked pain 3 96.16 Very High Very High Very High
allodynia 3 75.76 Quite High
Neuropathic pain 22 75.00 Quite High
Peripheral nerve injury 1 75.00 Quite High
Inflammation 1 73.12 Quite High
fluoxetine 6 64.36 Quite High
Desipramine 6 63.88 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 1 98.44 Very High Very High Very High
Nervous System Injury 7 97.56 Very High Very High Very High
Neuropathic Pain 30 96.16 Very High Very High Very High
INFLAMMATION 1 73.12 Quite High
Hypersensitivity 1 60.20 Quite High
Pain 2 59.52 Quite High
Myelodysplastic Syndromes 4 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no evidence to suggest that the significant increase in P2X4 mRNA also measured in activated C8-B4 cells led to elevated levels of P2X4 proteins (Table I).
Negative_regulation (measured) of Positive_regulation (increase) of P2X4 mRNA in C8-B4
1) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Why do pre-applications of antidepressants lead to a reduction in P2X4 receptor responses in activated C8-B4 cells (Fig. 12), even though these drugs do not inhibit P2X4 receptors directly (Fig. 11)?
Negative_regulation (reduction) of Positive_regulation (responses) of P2X4 in C8-B4 associated with antidepressant
2) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.50
Importantly, lyn(-/-) mice displayed impaired upregulation of the ionotropic ATP receptor subtype P2X(4) receptors (P2X(4)R) in the spinal cord after nerve injury, which is crucial for tactile allodynia.
Negative_regulation (impaired) of Positive_regulation (upregulation) of ATP receptor in spinal cord associated with brush evoked pain, nervous system injury and spinal cord
3) Confidence 0.17 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.36 Pain Relevance 0.97

[edit] General Comments

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