INT147113

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 18.24
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LTF) extracellular region (LTF) cytoplasm (LTF)
Anatomy Link Frequency
plasma 1
stigma 1
tear 1
pore 1
bowel 1
LTF (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain management 4 99.44 Very High Very High Very High
Inflammation 42 96.80 Very High Very High Very High
spastic colon 25 92.04 High High
Glutamate 1 78.84 Quite High
Pain 24 78.40 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic Filariasis 470 100.00 Very High Very High Very High
Onchocerciasis 52 100.00 Very High Very High Very High
Meningoencephalitis 5 100.00 Very High Very High Very High
Bacterial Respiratory Disease 2 100.00 Very High Very High Very High
Schistosomiasis 44 99.96 Very High Very High Very High
Alzheimer's Dementia 21 99.92 Very High Very High Very High
Infection 215 99.62 Very High Very High Very High
Disease 609 99.12 Very High Very High Very High
Pain 24 99.00 Very High Very High Very High
Inflammatory Bowel Disease 118 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The validated method was used to study the pharmacokinetic interaction of LF and an antiretroviral in 13 healthy volunteers.
LF Binding (interaction) of
1) Confidence 0.29 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 0 Pain Relevance 0
It has been reported that over 99% LF is bound to plasma proteins.3 Lindegardh and coworkers found protein precipitation prior to SPE increased recovery dramatically compared to SPE alone.6 The recovery in the reported method was in the range of 60%–75%.
LF Binding (bound) of in plasma
2) Confidence 0.24 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 0 Pain Relevance 0
Both lysozyme and lactoferrin which are major constituents of the tear film and possess antibacterial properties exhibited no significant effects on Acanthamoeba binding to and cytotoxicity of human corneal epithelial cells.
lactoferrin Binding (binding) of in tear associated with meningoencephalitis and bacterial respiratory disease
3) Confidence 0.23 Published 2008 Journal Int. J. Med. Microbiol. Section Abstract Doc Link 17931971 Disease Relevance 1.01 Pain Relevance 0.07
The information presented here indicates that helminth infections, especially the three major STH infections, schistosomiasis, LF, and onchocerciasis, account for up to 85% of the disease burden caused by NTDs in SSA (Table 6).
LF Binding (account) of associated with onchocerciasis, lymphatic filariasis, worm infection, disease, schistosomiasis and infection
4) Confidence 0.18 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 3.19 Pain Relevance 0
LF is also associated with huge economic losses, impairing economic activity up to 88% [9], and causes almost US$1 billion in annual losses, mostly resulting from the disability linked to hydrocele in men [95],[96].
LF Binding (associated) of associated with lymphatic filariasis and hydrocele
5) Confidence 0.15 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.27 Pain Relevance 0
LF is recognized as one of the most important neglected tropical diseases (NTDs), which are often characterized as diseases of poverty.
LF Binding (recognized) of associated with lymphatic filariasis and disease
6) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.87 Pain Relevance 0.10
This overall economic analysis of the GPELF's first 8 years does have notable limitations due to the lack of regionalized primary data concerning both epidemiological and socioeconomic factors associated with LF.
LF Binding (associated) of associated with lymphatic filariasis
7) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.54 Pain Relevance 0
Considering the disease burden of these three infections and their geographic overlap with LF, it is certain that an important reduction in these diseases is found in MDA treatment areas, resulting in health and economic benefits from prevention and diminution of stunting, anaemia, renal disease, and other complications [89], [90].


LF Binding (overlap) of associated with anaemia, lymphatic filariasis, renal disease, disease and infection
8) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.97 Pain Relevance 0
As a result of this study, fecal lactoferrin was found to be a sensitive and specific marker in measuring the activity of IBD and a valid method for discriminating between inflammatory and non-inflammatory bowel diseases.42
lactoferrin Binding (marker) of in bowel associated with inflammatory bowel disease and inflammation
9) Confidence 0.08 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 2.00 Pain Relevance 0.69
To date, however, no studies have estimated the economic value of these health benefits, either to the individuals or the societies afflicted with LF.
LF Binding (afflicted) of associated with lymphatic filariasis
10) Confidence 0.07 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2879371 Disease Relevance 0.91 Pain Relevance 0
The stigma associated with LF was a dominant theme in the accounts of most participants (see Box 1), which caused their condition to be hidden and contributed to delay in diagnosis with the subsequent advancement of the disease.
LF Binding (associated) of in stigma associated with lymphatic filariasis and disease
11) Confidence 0.05 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100378 Disease Relevance 0.98 Pain Relevance 0.08
We aimed to increase understanding of how this vulnerable, neglected group can be helped, by asking people with LF in Sri Lanka to recount their own experiences.
LF Binding (people) of associated with lymphatic filariasis
12) Confidence 0.04 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100378 Disease Relevance 0.99 Pain Relevance 0
Following binding of PA to cell surface receptors and internalization of toxin complexes, EF and LF are translocated into the cytoplasm through a heptamerized PA pore that forms at endosomal low pH [17–20].
LF Binding (binding) of in pore
13) Confidence 0.04 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 1.03 Pain Relevance 0
By comparison, rats injected with LF and either 20 ?
LF Binding (injected) of
14) Confidence 0.04 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.57 Pain Relevance 0
g of this mutant protein and LF (TTD = 68.5 [±5.0] minutes compared to those of three animals in each group that received LF with either 20, 30, or 40 ?
LF Binding (received) of associated with death
15) Confidence 0.04 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.54 Pain Relevance 0
Rats injected with LF and 100 ?
LF Binding (injected) of
16) Confidence 0.04 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.58 Pain Relevance 0
Peptide fragmentation has been shown to trigger amyloid fibril aggregations of lactoferrin, amyloid-?
lactoferrin Binding (aggregations) of associated with alzheimer's dementia
17) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790481 Disease Relevance 0.34 Pain Relevance 0.04

General Comments

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