INT147263

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2011
Negated 6
Speculated 1
Reported most in Body
Documents 51
Total Number 52
Disease Relevance 15.32
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 16
retina 6
spinal cord 4
skin 4
radial 2
Tg(CAG-EGFP)D4Nagy (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 319 99.32 Very High Very High Very High
Dorsal horn neuron 24 99.22 Very High Very High Very High
Glutamate 37 99.20 Very High Very High Very High
Dopamine 10 99.20 Very High Very High Very High
hyperexcitability 2 98.20 Very High Very High Very High
Nucleus accumbens 13 97.40 Very High Very High Very High
gABA 81 95.80 Very High Very High Very High
Spinal cord 216 94.72 High High
ketamine 13 94.72 High High
Anterior cingulate cortex 128 94.32 High High
Disease Link Frequency Relevance Heat
Cold Sores 408 100.00 Very High Very High Very High
Cancer 297 100.00 Very High Very High Very High
Cytomegalovirus Infection 103 100.00 Very High Very High Very High
Targeted Disruption 344 99.88 Very High Very High Very High
Generalized Anxiety Disorder 5 99.20 Very High Very High Very High
Skin Cancer 33 97.16 Very High Very High Very High
Aging 26 95.68 Very High Very High Very High
Handedness 25 95.44 Very High Very High Very High
Diabetes Mellitus 20 93.80 High High
Wound Healing 24 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, electrotransfer of an unrelated siRNA (negative siRNA) did not lead to changes in eGFP expression as compared with the other controls.
Regulation (changes) of Gene_expression (expression) of eGFP
1) Confidence 0.53 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.49 Pain Relevance 0.04
This observed silencing was neither due to the electric treatment nor the siRNAs alone: Without the application of the electric field, siRNAs failed to enter the cells (Figure 3), and did not show detectable silencing of eGFP expression (Figure 2); furthermore, the electric field alone had no effect on eGFP expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of eGFP
2) Confidence 0.53 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.05 Pain Relevance 0
As expected the electrical treatment itself (PBS+EP) had no effect on eGFP expression in tumor.
Neg (no) Regulation (effect) of Gene_expression (expression) of eGFP associated with cancer
3) Confidence 0.53 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.50 Pain Relevance 0.04
The intensity and duration of GFP expression were dependent on the injection route, viral titer, and treatment with antiCD40L antibody.
Regulation (dependent) of Gene_expression (expression) of GFP
4) Confidence 0.40 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.16 Pain Relevance 0
GFP expression in the tumor cells was detected directly through the skin in the anesthetized animal by digitized fluorescence stereomicroscopy.
Regulation (detected) of Gene_expression (expression) of GFP in skin associated with cancer
5) Confidence 0.39 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.27 Pain Relevance 0.25
Furthermore, we defined experimental systems to visualize and quantify down-regulation of a constitutively expressed eGFP reporter gene, and the localization of siRNAs in subcutaneous B16-F10 melanoma tumors using fluorescence imaging.
Regulation (regulation) of Gene_expression (expressed) of eGFP in B16-F10 associated with cancer, skin cancer and imagery
6) Confidence 0.39 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.37 Pain Relevance 0.09
Subretinal injection of AC-GFP and TFA-GFP was extremely effective in producing EGFP expression in the PECS and retina.
Regulation (effective) of Gene_expression (injection) of AC-GFP in retina
7) Confidence 0.34 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0.07 Pain Relevance 0
Surprisingly, as demonstrated in Figure 4, there was no change in GFP protein expression between the ages of 6 to 18 months in the cortex (F?
Neg (no) Regulation (change) of Gene_expression (expression) of GFP in cortex
8) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.42 Pain Relevance 0.15
Single microinjection of vector expressing EGFP under a CMV promoter control (LV-EGFP) allowed vector diffusion along a rostro-caudal axis but strictly restricted to the grey matter of the ipsilateral dorsal spinal cord.
Regulation (control) of Gene_expression (expressing) of EGFP in spinal cord associated with cytomegalovirus infection and spinal cord
9) Confidence 0.25 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 17949823 Disease Relevance 0.50 Pain Relevance 0.44
The intensity and extensiveness of distribution of GFP expression depended on the viral titer used.
Regulation (depended) of Gene_expression (expression) of GFP
10) Confidence 0.24 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.08 Pain Relevance 0
We also followed the effect of electrical treatment on knockdown of eGFP expression knockdown with siRNAs, in vivo.
Regulation (effect) of Gene_expression (expression) of eGFP
11) Confidence 0.23 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.05 Pain Relevance 0.04
Fluorescent microscopy at 48 h post-transduction revealed that transduction with HSV-U6shLacZ had no effect on GFP expression levels, whereas transduction with HSV-U6shGFP resulted in almost complete inhibition of GFP expression (Figure 4).
Neg (no) Regulation (effect) of Gene_expression (expression) of GFP associated with cold sores
12) Confidence 0.22 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.62 Pain Relevance 0.08
Fluorescent microscopy at 48hrs post-transduction revealed that transduction with HSV-U6shLacZ had no effect on GFP expression levels, whereas transduction with HSV-U6shGFP resulted in a dramatic reduction in the levels of GFP compared to control groups (magnification 10×).


Neg (no) Regulation (effect) of Gene_expression (expression) of GFP associated with cold sores
13) Confidence 0.22 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.62 Pain Relevance 0.16
protein and mRNA transgene expression levels respectively in the Degron model, GFP is most highly expressed in cortical, subcortical, hippocampal, and cerebellar regions (see Figure 1A–B, I).
Regulation (respectively) of Gene_expression (expressed) of GFP
14) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.31 Pain Relevance 0.09
To target nanoparticle driven expression of EGFP in the photoreceptors and RPE, we delivered 1 µL of AC-GFP, TFA-GFP, or naked plasmid to the retina by a subretinal injection.
Regulation (target) of Gene_expression (expression) of EGFP in photoreceptors
15) Confidence 0.20 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0.09 Pain Relevance 0
To address this question by developing a sensitive detection method, we generated transgenic mice expressing enhanced green fluorescent protein (GFP) under the specific transcriptional control of the PPE gene.
Regulation (under) of Gene_expression (expressing) of GFP associated with targeted disruption
16) Confidence 0.20 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 19046386 Disease Relevance 0.27 Pain Relevance 0.12
A control lentivector expressing only GFP did not affect in situ signals (n?
Regulation (control) of Gene_expression (expressing) of GFP
17) Confidence 0.14 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.30 Pain Relevance 0.03
It is likely that, in our experiments, the low levels of GFP in SG are due to the limited targeting of neurons smaller than 22 ?
Regulation (due) of Gene_expression (levels) of GFP in neurons
18) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2900238 Disease Relevance 0 Pain Relevance 0.38
To determine their ultimate fate, we performed chronic in vivo two-photon imaging of identified CR neurons during postnatal development in mice that express the green fluorescent protein (GFP) under the control of the early B-cell factor 2 (Ebf2) promoter.
Regulation (under) of Gene_expression (express) of GFP in neurons associated with imagery
19) Confidence 0.11 Published 2010 Journal Frontiers in Neuroanatomy Section Abstract Doc Link PMC2845061 Disease Relevance 0.15 Pain Relevance 0.05
Finally, GFP expression in BHK-LacZ cells transduced with HSV-miR vectors was not affected by expression of miR-LacZ as evaluated by fluorescent microscopy (Figure 3a).
Neg (not) Regulation (affected) of Gene_expression (expression) of GFP associated with cold sores
20) Confidence 0.10 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.21 Pain Relevance 0

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