INT147403

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.45
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
mononuclear cells 4
telomere 2
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 36 99.38 Very High Very High Very High
Kinase C 423 96.24 Very High Very High Very High
Chronic pancreatitis 1 78.36 Quite High
Inflammation 51 50.00 Quite Low
Central nervous system 9 31.96 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 184 98.68 Very High Very High Very High
Targeted Disruption 18 98.24 Very High Very High Very High
Carcinoma 1 92.08 High High
Cervical Cancer 9 88.32 High High
Adenoma 1 86.00 High High
Increased Venous Pressure Under Development 9 83.40 Quite High
Pancreatitis 1 78.36 Quite High
Apoptosis 29 77.84 Quite High
Adenocarcinoma 2 76.80 Quite High
Keloid Scars 103 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulated human telomerase reverse transcriptase expression was detectable and increased gradually with cancer development and was primarily observed at the borderline IPMN stage and then in more advanced histopathologies.
Regulation (regulated) of Gene_expression (expression) of telomerase reverse transcriptase associated with cancer
1) Confidence 0.27 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.29 Pain Relevance 0.08
The Receptor Ck-dependent down-regulation of hTERT mRNA expression observed in the present study may cooperate with the other repressive mechanisms operational in PBMCs in order to maintain appropriate low levels of telomerase in these cells.
Regulation (regulation) of Gene_expression (expression) of hTERT mRNA
2) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.46 Pain Relevance 0
On the other hand, c-myc and hTERT mRNA expression exhibited a dose-dependent decrease (Figure 6), thus implicating the transcription factor, PPAR?
Regulation (exhibited) of Gene_expression (expression) of hTERT mRNA
3) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.09
Telomere attrition even in the presence of telomerase suggests that the level of hTERT and telomerase expression is insufficient for the maintenance of telomere lengths.
Regulation (insufficient) of Gene_expression (expression) of hTERT in telomere
4) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.48 Pain Relevance 0.05
silencing on hTERT gene transcription. hTERT mRNA expression was found to increase in PPAR?
Regulation (found) of Gene_expression (expression) of hTERT mRNA
5) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.20
Taken together, the findings of this study present evidence for a molecular link between cholesterol-activated Receptor Ck and hTERT transcription, and provide new insights into the regulation of hTERT expression in normal human peripheral blood mononuclear cells.



Regulation (regulation) of Gene_expression (expression) of hTERT in mononuclear cells
6) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.13
resulted in the down-regulation of c-myc and hTERT mRNA expression.
Regulation (regulation) of Gene_expression (expression) of hTERT mRNA
7) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.07 Pain Relevance 0.14
by its agonist pioglitazone was found to down-regulate the mRNA expression of c-myc and hTERT genes in PBMCs (Figure 6).
Regulation (-) of Gene_expression (expression) of hTERT associated with agonist
8) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.43
by its agonist pioglitazone was found to down-regulate the mRNA expression of c-myc and hTERT genes in PBMCs (Figure 6).
Regulation (regulate) of Gene_expression (expression) of hTERT associated with agonist
9) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.43
Hence, the cellular models employed in the present study were the normal human peripheral blood mononuclear cells (PBMCs), which are known to express hTERT and telomerase in a highly regulated manner.
Regulation (regulated) of Gene_expression (express) of hTERT in mononuclear cells
10) Confidence 0.11 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.40 Pain Relevance 0
To further delineate the relationship of IL-6 and IL-17 in the regulation of hTERT and Oct-4 expression in SKPs and KPCs, we pretreated cells with neutralizing antibody for either IL-17, or IL-6, or both followed by IL-17 exposure.
Regulation (regulation) of Gene_expression (expression) of hTERT
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.08 Pain Relevance 0

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