INT147440

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.61
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Nox1) signal transduction (Nox1) transport (Nox1)
oxidoreductase activity (Nox1) plasma membrane (Nox1) extracellular matrix organization (Nox1)
Anatomy Link Frequency
PSCs 2
smooth muscle 1
Nox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 98.12 Very High Very High Very High
chemokine 2 86.80 High High
fibrosis 8 68.64 Quite High
Inflammation 6 66.20 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 4 98.12 Very High Very High Very High
Targeted Disruption 1 95.80 Very High Very High Very High
Hypertension 14 95.08 Very High Very High Very High
Stroke 1 90.52 High High
Primary Sclerosing Cholangitis 2 89.84 High High
Hypertrophy 5 89.72 High High
Fibrosis 9 68.64 Quite High
Stress 10 67.16 Quite High
INFLAMMATION 6 66.20 Quite High
Cardiovascular Disorder Under Development 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSCs expressed key components of NADPH oxidase (p22(phox), p47(phox), NOX1, gp91(phox)/NOX2, NOX4, and NOX activator 1).
Gene_expression (expressed) of NOX1 in PSCs
1) Confidence 0.57 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962358 Disease Relevance 0.51 Pain Relevance 0.30
PSCs expressed key components of NADPH oxidase (p22(phox), p47(phox), NOX1, gp91(phox)/NOX2, NOX4, and NOX activator 1).
Gene_expression (expressed) of NOX activator 1 in PSCs
2) Confidence 0.57 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962358 Disease Relevance 0.52 Pain Relevance 0.31
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Gene_expression (expression) of Nox1 in smooth muscle associated with targeted disruption and hypertrophy
3) Confidence 0.40 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.58 Pain Relevance 0

General Comments

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