INT147447

Context Info Confidence 0.50 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.12 Pain Relevance 1.15

nucleoplasm (RELA) aging (RELA) DNA binding (RELA) cytoplasm (RELA) cell-cell signaling (ADCYAP1) cytosol (RELA)

Anatomy Link Frequency PBMC 2 ADCYAP1 (Homo sapiens) RELA (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 11 99.84 Inflammation 3 97.76 cytokine 2 89.52 Neuropeptide 2 75.00 Inflammatory response 1 75.00 Pain 5 55.84

Disease Link Frequency Relevance Heat Pancreatitis 11 99.84 INFLAMMATION 4 97.76 Apoptosis 1 77.20 Nociception 1 74.64 Disease 1 57.68 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The change of PACAP-mediated anti-inflammatory pattern was associated with altered activation of NF-kappaB: compared with LPS alone, a combination of LPS and PACAP had no effect on NF-kappaB p65 nuclear translocation in CP PBMC, whereas NF-kappaB was significantly decreased in donor PBMC.

PACAP Neg (no) Regulation (effect) of Localization (translocation) of p65 in PBMC associated with inflammation and chronic pancreatitis

1) Confidence 0.50 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 1.12 Pain Relevance 1.15

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