INT147517

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 3.46
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
CAR 2
cleavage 2
ovary 2
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 262 100.00 Very High Very High Very High
Potency 80 98.24 Very High Very High Very High
Inflammation 85 95.24 Very High Very High Very High
metalloproteinase 173 95.20 Very High Very High Very High
Arthritis 8 93.24 High High
imagery 6 92.16 High High
Osteoarthritis 24 80.16 Quite High
antagonist 42 79.12 Quite High
Paracetamol 3 77.80 Quite High
fibrosis 9 71.72 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 43 99.04 Very High Very High Very High
Targeted Disruption 15 97.20 Very High Very High Very High
Breast Cancer 16 97.12 Very High Very High Very High
INFLAMMATION 113 95.24 Very High Very High Very High
Reprotox - General 3 24 94.24 High High
Arthritis 18 93.24 High High
Cancer 28 88.84 High High
Obesity 88 87.20 High High
Apoptosis 40 84.08 Quite High
Endometroid Carcinoma 5 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detailed study addressing expression of PPAR?
Negative_regulation (addressing) of Gene_expression (expression) of PPAR
1) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.17 Pain Relevance 0
expression levels of PPAR?
Negative_regulation (levels) of Gene_expression (expression) of PPAR
2) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0.05
A recent in vitro study demonstrated an inhibition of the expression of PPAR ?
Negative_regulation (inhibition) of Gene_expression (expression) of PPAR
3) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.61 Pain Relevance 0.71
1 and/or PPAR agonists (added 2?
Negative_regulation (added) of Gene_expression (agonists) of PPAR associated with agonist
4) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.37
Our data demonstrates that PPAR agonists reduce TGF-?
Negative_regulation (reduce) of Gene_expression (agonists) of PPAR associated with agonist
5) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.57 Pain Relevance 0.60
as

ICI was previously shown to inhibit the action of the selective PPAR?

Negative_regulation (inhibit) of Gene_expression (selective) of PPAR
6) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.46 Pain Relevance 0.05
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
Negative_regulation (influence) of Gene_expression (expression) of PPARalpha in CAR
7) Confidence 0.25 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.28
in the ovary and siRNA or similar technologies to reduce expression of PPAR?
Negative_regulation (reduce) of Gene_expression (expression) of PPAR in ovary
8) Confidence 0.20 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.19 Pain Relevance 0
Despite a variable contribution of the PPAR?
Negative_regulation (Despite) of Gene_expression (contribution) of PPAR
9) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.22 Pain Relevance 0.24
As a corollary, the efficient overexpression of PPAR?
Negative_regulation (efficient) of Gene_expression (overexpression) of PPAR
10) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.21
Disrupting the expression of PPAR?
Negative_regulation (Disrupting) of Gene_expression (expression) of PPAR
11) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0
The periovulatory expression pattern of PPAR?
Negative_regulation (pattern) of Gene_expression (expression) of PPAR
12) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.16 Pain Relevance 0.05
and P450 side-chain cleavage, and reduction in expression of PPAR?
Negative_regulation (reduction) of Gene_expression (expression) of PPAR in cleavage
13) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.50 Pain Relevance 0
The inverse expression of PPAR?
Negative_regulation (inverse) of Gene_expression (expression) of PPAR
14) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.51 Pain Relevance 0

General Comments

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