INT147582

From wiki-pain
Revision as of 09:19, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 13.26
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
spinal cord 1
uterine 1
AIS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 186 100.00 Very High Very High Very High
cva 84 99.48 Very High Very High Very High
Pain 56 99.48 Very High Very High Very High
Multiple sclerosis 15 98.96 Very High Very High Very High
imagery 49 98.12 Very High Very High Very High
Dismenorea 13 97.36 Very High Very High Very High
agonist 16 97.28 Very High Very High Very High
rheumatoid arthritis 2 96.64 Very High Very High Very High
Analgesic 4 94.80 High High
Nav1.2 1 82.52 Quite High
Disease Link Frequency Relevance Heat
Scoliosis 606 100.00 Very High Very High Very High
Cervical Intraepithelial Neoplasia 34 100.00 Very High Very High Very High
Cervical Cancer 81 99.80 Very High Very High Very High
Papillomavirus Infection 360 99.52 Very High Very High Very High
Cv General 3 Under Development 65 99.48 Very High Very High Very High
Pain 50 99.48 Very High Very High Very High
Cardiovascular Disease 29 99.38 Very High Very High Very High
Arthralgia 102 99.12 Very High Very High Very High
Reprotox - General 1 126 99.04 Very High Very High Very High
Demyelinating Disease 15 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The risk of any event is reduced with AIs by 23%, with an absolute benefit of 3.8% (Bria et al 2006).
Negative_regulation (reduced) of AIs
1) Confidence 0.37 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.40 Pain Relevance 0
However, in this trial, as well as other postadjuvant or switching studies, it is difficult to deduce whether the cardiovascular adverse events observed may be attributed, at least in part, to the effects of prior tamoxifen or whether these events are a true effect of the AIs.
Spec (whether) Negative_regulation (effect) of AIs
2) Confidence 0.37 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.67 Pain Relevance 0
Therefore, the ratio of cord length/vertebral length was significantly reduced in severe AIS (ratio = 0.67) compared with the normal controls (ratio = 0.72).
Negative_regulation (reduced) of AIS associated with scoliosis
3) Confidence 0.34 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.99 Pain Relevance 0.25
Porter [28] stated that the putative impaired growth of the spinal cord in AIS may result from an abnormal response to stretch including: 1) inadequate cord growth from deficient hormonal environment; 2) cell membrane defect with abnormal function of contractile proteins in cells of the spinal cord as part of a systemic disorder; 3) abnormality of the elastin fibre system, 4) failure of melatonin to scavenge free radicals resulting in spinal cord stretch injury; and 5) hypoxia.


Negative_regulation (impaired) of AIS in spinal cord associated with scoliosis, hypoxia, injury and spinal cord
4) Confidence 0.33 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.67 Pain Relevance 0.27
Other criteria (greater number of AIS, greater AIS diameter, infratentorial location and gadolinium enhancement) should be used, in order to improve the specificity, only to the MRIs of elderly patients (> 50 years) with suspected MS or patients suspected of MS in whom alternative explanations seem equally similar.
Negative_regulation (number) of AIS associated with multiple sclerosis
5) Confidence 0.30 Published 1997 Journal Srp Arh Celok Lek Section Abstract Doc Link 17974350 Disease Relevance 0.54 Pain Relevance 0.38
Early discontinuation of AIs may result in an inadequate clinical response.
Negative_regulation (discontinuation) of AIs
6) Confidence 0.27 Published 2010 Journal Clin J Oncol Nurs Section Abstract Doc Link 20529801 Disease Relevance 0.50 Pain Relevance 0.09
Of serious concern for prevention is the potential for increase in risk of bone fracture and cardiovascular disease related to long-term estrogen depletion with AIs.
Negative_regulation (depletion) of AIs associated with bone fracture and cardiovascular disease
7) Confidence 0.25 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 1.10 Pain Relevance 0.14
Adverse events associated with tamoxifen include increased risk of uterine cancers and thromboembolic events vs. an increased incidence of vaginal dryness, loss of libido, musculoskeletal pain and bone mineral density loss with AIs.
Negative_regulation (loss) of AIs in uterine associated with reprotox - general 2, pain, uterine cancer, cva and reprotox - general 1
8) Confidence 0.25 Published 2007 Journal International Journal of Clinical Practice Section Abstract Doc Link PMC2228389 Disease Relevance 0.73 Pain Relevance 0.15
It is hypothesized that when AIs decrease estrogen levels, light-induced melatonin suppression (LIMS) loses efficacy, leading to an abnormal melatonin cycle as seen in rheumatoid arthritis patients, producing (via mechanisms not yet understood) the symptoms of morning stiffness.
Negative_regulation (decrease) of AIs associated with rheumatoid arthritis
9) Confidence 0.21 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18782656 Disease Relevance 0.62 Pain Relevance 0.37
Class effects of AIs, favorable to AIs
Negative_regulation (effects) of AIs
10) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 0.52 Pain Relevance 0.05
Class effects of AIs, favorable to tamoxifen
Negative_regulation (effects) of AIs
11) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 0.98 Pain Relevance 0.25
Third-generation AIs, however, are potent inhibitors of oestrogen synthesis and have all been shown to significantly reduce the risk of thromboembolism compared with tamoxifen treatment in postmenopausal women with breast cancer.
Negative_regulation (reduce) of AIs associated with breast cancer and cva
12) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 1.30 Pain Relevance 0.39
In this group there was an 18% reduction in CIN 2/3 or AIS due to any HPV type.
Negative_regulation (reduction) of AIS associated with papillomavirus infection and cervical intraepithelial neoplasia
13) Confidence 0.05 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971720 Disease Relevance 2.03 Pain Relevance 0
Kv2.1 localization in a single proximal neurite with diminished MAP2 staining, i.e. the AIS (marked by the arrow in Fig. 3), was observed in 35% of 7 DIV neurons and 63% of 10 DIV neurons (200 neurons examined in each of three experiments).
Negative_regulation (diminished) of AIS in neurons
14) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0 Pain Relevance 0.11
A secondary aim was to observe whether the administration of vaccine reduced the combined incidence of CIN grades 1–3, AIS, or cervical cancer associated by vaccine type HPV.
Spec (whether) Negative_regulation (reduced) of AIS associated with papillomavirus infection, cervical cancer and cervical intraepithelial neoplasia
15) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971720 Disease Relevance 2.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox