INT147675

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.07

signal transduction (GRP) extracellular space (GRP) extracellular region (GRP) nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)

Anatomy Link Frequency SCN 2 Atf2 (Mus musculus) GRP (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 1 74.96

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we tested the putative role of GRP as an intra-SCN light signal at the behavioral and cellular levels, and we also tested whether GRP actions are dependent on activation of the cAMP response element-binding protein (CREB) pathway and Per1.

Spec (853) Positive_regulation (activation) of cAMP response element-binding protein in SCN Spec (whether) Positive_regulation (dependent) of GRP

1) Confidence 0.04 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.07

General Comments

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