INT147732

Context Info Confidence 0.36 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.13 Pain Relevance 0.20

cytosol (PIK3CA) signal transduction (PIK3CA)

Anatomy Link Frequency epithelial cells 1 PIK3CA (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 2 83.52 cytokine 2 82.00 Opioid 1 55.92 tolerance 7 5.00 Potency 3 5.00 ketamine 2 5.00 anesthesia 2 5.00 Inflammation 1 5.00 Kinase C 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 1 99.12 Breast Cancer 36 99.00 Cancer 56 90.60 Hyperinsulinism 2 85.32 Skin Cancer 2 58.72 Diabetes Mellitus 7 58.08 Hematologic Neoplasms 2 57.68 Solid Tumor 2 56.44 Insulin Resistance 24 50.00 Targeted Disruption 8 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ala mice also showed an increased association between IRS-1 and the p85 subunit of PI3-kinase, which reflects increased interaction between IRS-1 and PI 3-kinase likely due to the Ser612?

PI 3-kinase Binding (interaction) of

1) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.14 Pain Relevance 0.08

In addition to ER, a number of other HSP90 client proteins have been shown to be involved in breast cancer progression such as those that are important for signaling through the phosphahtidylinositol-3-kinase (PI3K/p110?)

PI3K Binding (signaling) of associated with breast cancer

2) Confidence 0.10 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.75 Pain Relevance 0.04

We have recently identified a specific signaling pathway that regulates actin reorganization in malignant human breast and prostate epithelial cells associated with FAK, PI-3K and Rac1 activation.

PI-3K Binding (associated) of in epithelial cells associated with malignant neoplastic disease

3) Confidence 0.08 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

This test has worked.