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Context Info
Confidence 0.38
First Reported 1991
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.28
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cck, Gast) signal transduction (Gast) extracellular space (Cck)
Anatomy Link Frequency
plasma 1
Cck (Rattus norvegicus)
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 39 100.00 Very High Very High Very High
Central nervous system 4 100.00 Very High Very High Very High
antagonist 8 99.60 Very High Very High Very High
tetrodotoxin 1 89.60 High High
Dopamine 1 76.32 Quite High
analgesia 1 75.76 Quite High
ischemia 3 75.00 Quite High
substance P 3 75.00 Quite High
qutenza 3 64.00 Quite High
Neuropeptide 1 63.48 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 75.32 Quite High
Cv Unclassified Under Development 3 75.00 Quite High
Disease 1 56.88 Quite High
Obesity 1 30.24 Quite Low
Increased Venous Pressure Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This protective effect of leptin was accompanied by a significant increase in GBF and plasma gastrin levels whereas CCK-8 increased plasma leptin levels but failed to affect plasma gastrin levels.
CCK-8 Neg (failed) Regulation (affect) of gastrin in plasma
1) Confidence 0.38 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787760 Disease Relevance 0.15 Pain Relevance 0.27
To clarify this, we compared the effects of CCK-8 sulfate, CCK-4 and gastrin in radioligand binding studies and longitudinal ileal contractility in vitro.
CCK Regulation (effects) of gastrin associated with cholecystokinin
2) Confidence 0.03 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1704435 Disease Relevance 0 Pain Relevance 0.80
CCK-AR, found predominantly in the GI system and select areas of the CNS, have high affinity for CCK and the nonpeptide antagonist L-364,718, whereas CCK-BR, found predominantly in the CNS and select areas of the GI system, have high affinity for CCK and gastrin and the nonpeptide antagonist L-365,260.
CCK Regulation (affinity) of gastrin in CNS associated with antagonist, central nervous system and cholecystokinin
3) Confidence 0.02 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7491953 Disease Relevance 0.13 Pain Relevance 1.23

General Comments

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