INT147982

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0.32

cytoplasm (Cpox, Ptgds) isomerase activity (Ptgds) transport (Ptgds) mitochondrion (Cpox) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds)

Cpox (Mus musculus) Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 3 99.24 Spinal cord 2 76.04 allodynia 1 69.36 Hyperalgesia 1 68.80 cytokine 3 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 3 99.24 Neuropathic Pain 1 69.36 Hyperalgesia 1 68.80 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It can be assumed, that PGD2 biosynthesis under control conditions is mediated via COX-1 and that during inflammation, increased PGD2 is dependent on COX-2.

COX Positive_regulation (mediated) of Gene_expression (biosynthesis) of PGD2 associated with inflammation

1) Confidence 0.17 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.30 Pain Relevance 0.32

General Comments

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