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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A2) signal transduction (NR4A2) nucleus (NR4A2)
cytoplasm (NR4A2)
Anatomy Link Frequency
melanocytes 2
NR4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 96.36 Very High Very High Very High
Nucleus accumbens 1 89.00 High High
Ventral tegmentum 4 87.28 High High
midbrain 2 81.76 Quite High
Kappa opioid receptor 1 80.40 Quite High
Dopamine 7 75.00 Quite High
melanocortin 1 receptor 2 75.00 Quite High
Opioid 2 75.00 Quite High
opiate 1 50.24 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 99.48 Very High Very High Very High
Skin Cancer 4 84.00 Quite High
Congenital Anomalies 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the results revealed an exaggerated reduction of Nurr1 expression with age in heroin users (r = -0.8268, p < 0.001 vs controls, r = -0.6204, p = 0.0746).
Negative_regulation (reduction) of Gene_expression (expression) of Nurr1 associated with opiate addiction
1) Confidence 0.55 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.41 Pain Relevance 0.73
Using small interference RNA-mediated attenuation of NR4A1 and NR4A2 expression in melanocytes, the ability to remove cyclobutane pyrimidine dimers following UV irradiation appeared to be impaired in the context of MC1R signaling.
Negative_regulation (attenuation) of Gene_expression (expression) of NR4A2 in melanocytes
2) Confidence 0.36 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18292087 Disease Relevance 0.30 Pain Relevance 0.18

General Comments

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